BACKGROUND Secondary cultures of human fibroblasts display a finite lifespan ending at senescence. Loss of p53 function by mutation or viral oncogene expression bypasses senescence, allowing cell division to continue for an additional 10-20 doublings. During this time chromosomal aberrations seen in mitotic cells increase while DNA damage and decatenation checkpoint functions in G2 cells decrea...

The pK(a) of (Asp(158))-CO(2)H of papain (EC 3.4.22.2) was determined as 2.8 by using 4-chloro-7-nitrobenzofurazan (Nbf-Cl) as a reactivity probe targeted on the thiolate anion component of the Cys(25)/His(159) nucleophilic-acid/base motif of the catalytic site. The possibility of using Nbf-Cl for this purpose was established by modelling the papain-Nbf-Cl Meisenheimer intermediate by using QUA...

The objective was to characterize endometrial transcriptome on d 17 of gestation in dairy cows according conceptus length. Nonlactating Holstein (n = 48) were euthanized after AI and the uterine horn ipsilateral CL flushed with saline solution. Recovered conceptuses classified as small (1.2 6.9 cm; n 9), medium (10.5 16.0 or large (18.0 26.4 10). Samples intercaruncular endometrium dissected fr...

Background: To evaluate impact of spironolactone (S) on pulmonary toxicity of concomitant use of thoracic radiotherapy (RT) and trastuzumab (T).  Materials and Methods: Eighty rats were divided into eight groups: group (G) 1 was control group; G2, G3 and G4 were RT, S and T groups; G5, G6, G7 and G8 were RT+T, T+S, RT+S and RT+T+S groups respectively. Rats were sacrificed at 6 hour, 21 and 100 ...

OF DOCTORAL DISSERTATION AALTO UNIVERSITY SCHOOL OF SCIENCE AND TECHNOLOGY P.O. BOX 11000, FI-00076 AALTO http://www.tkk.fi Author Tuula Lehtimaa Name of the dissertation Reactions of Chlorine (III) and Their Kinetics in the Chlorine Dioxide Bleaching of Kraft Pulps Manuscript submitted February 9, 2010 Manuscript revised May 12, 2010 Date of the defence June 21, 2010 Monograph Article disserta...

Hybrid quantum systems usually consist of two or more subsystems, which may take the advantages of the different systems. Recently, the hybrid system consisting of circuit electromechanical subsystems have attracted great attention due to its advanced fabrication and scalable integrated photonic circuit techniques. Here, we propose a scheme for high fidelity quantum state transfer between a sup...

"Changing-look" active galactic nuclei (CL-AGNs) are a newly-discovered class of AGNs that show the appearance (or disappearance) broad emission lines within short time scale (months to years) and often associated with dramatic change their continuum emissions. They provide us an unprecedented chance directly investigate host galaxy properties minimal contamination from luminous central engine ...

This paper introduces the concept of certificateless public key cryptography (CL-PKC).In contrast to traditional public key cryptographic systems, CL-PKC does not require theuse of certificates to guarantee the authenticity of public keys. It does rely on the useof a trusted third party (TTP) who is in possession of a master key. In these respects,CL-PKC is similar to identity-b...