نتایج جستجو برای: fusion protein vaccine

تعداد نتایج: 1413089  

Journal: :Cancer science 2008
Sun-Je Woo Chang-Hyun Kim Mi-Young Park Hye-Sung Kim Hyun-Jung Sohn Jung-Sun Park Hyung-Jin Kim Seong-Taek Oh Tai-Gyu Kim

Although dendritic cells (DC) have been well demonstrated as a strong cellular adjuvant for a tumor vaccine, there are several limitations for clinical application. A protein-based vaccine using a potent adjuvant is an appealing approach for tumor antigen-specific immunotherapy because of their simplicity, safety, efficacy and capacity for repeated administration. CpG-oligodeoxynucleotides (ODN...

Abbas Rezaee Ali Delpisheh Bahman Tabbaraee Iraj Pakzad, Mohammad Javad Rasaee,

Background: The immunogenic Brucella abortus ribosomal protein L7/L12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. Objective: This study was aimed to evaluate the protection of recombinant Human Serum Albumin (HAS)-L7/L12 fusion protein in Balb/c mice. Methods: The amplified L7/L12 gene was cloned in pYHSA5 vector, pYHSA5-L7/L12 construct was tra...

Journal: :Journal of microbiology and biotechnology 2015
Eunji Yang Yonggeun Cho Jung-Ah Choi YoungJoo Choi Pil-Gu Park Eunsun Park Choong Hwan Lee Hyeja Lee Jongsun Kim Jae Myun Lee Manki Song

Current influenza vaccines are produced in embryonated chicken eggs. However, egg-based vaccines have various problems. To address these problems, recombinant protein vaccines have been developed as new vaccine candidates. Unfortunately, recombinant proteins frequently encounter aggregation and low stability during their biogenesis. It has been previously demonstrated that recombinantly express...

John.C. Bell, Taravat Bamdad,

The herpes simplex virus type 1 (HSV-1) tegument protein, VP22 has been reported to have the property of intercellular transport. The previous studies have shown that following expression of a fusion protein containing VP22 it spreads to every cell in a monolayer and concentrates in the nucleus. In spite of these reports, some studies have shown that VP22 trafficking and its nucleus accumulatio...

Journal: :cell journal 0

objective: for immunotherapy of human papillomavirus (hpv) -16-associated cervical cancers the e7 protein is considered a prime candidate. however it is a poor inducer of cytotoxic t-cell response, when being used as a singular antigen in protein vaccination. hence, in this study we focused on the utilization of a vaccine delivery system for prevention or treatment of cervical cancer. materials...

Journal: :Infection and immunity 2015
Huafeng Wang Mengyi Li Tassanee Lerksuthirat Bruce Klein Marcel Wüthrich

C-type lectin receptors (CLRs) are essential in shaping the immune response to fungal pathogens. Vaccine-induced resistance requires Dectin-2 to promote differentiation of antifungal Th1 and Th17 cells. Since Dectin-2 and MCL heterodimerize and both CLRs use FcRγ as the signaling adaptor, we investigated the role of MCL in vaccine immunity to the fungal pathogen Blastomyces dermatitidis. MCL(-/...

Behrokh Farahmand , Farida Behzadian , Fatemeh Fotouhi-Chahooki , Mahdi Tat , Zahra Yousefi-Najafabadi ,

Background and Aims: The novel approaches in influenza vaccination have targeted more conserved viral proteins such as nucleoprotein (NP) to provide cross protection against all serotypes of influenza A viruses. Influenza specific cytotoxic T lymphocytes (CTL) are able to lyse influenza-infected cells by recognition of NP, the major target molecule in virus for CTL responses. On the other hand,...

2017
Martin Fraiberk Michaela Hájková Magdaléna Krulová Martina Kojzarová Alena Drda Morávková Ivan Pšikal Jitka Forstová

The aim of this study was to develop a suitable vaccine antigen against porcine circovirus 2 (PCV2), the causative agent of post-weaning multi-systemic wasting syndrome, which causes significant economic losses in swine breeding. Chimeric antigens containing PCV2b Cap protein sequences based on the mouse polyomavirus (MPyV) nanostructures were developed. First, universal vectors for baculovirus...

2017
Sobhan Faezi Ahmad Reza Bahrmand Seyed Davar Siadat Iraj Nikokar Soroush Sardari Mehdi Mahdavi

OBJECTIVES Infection with Pseudomonas aeruginosa has been a long-standing obstacle for clinical therapy due to the complexity of the genetics and pathogenesis, as well for widespread resistance to antibiotics, thus attaching great importance to explore effective vaccines for prevention and treatment. This paper focuses on the introduction of novel Pseudomonas aeruginosa type IV pili (T4P)-based...

Journal: :modares journal of medical sciences: pathobiology 2010
kami hoseinian khosroshahi fatemeh ghaffarifar zohre sharifi sashila desouza abdolhosein dalimi

objective: toxoplasma gondii is an obligate intracellular protozoan that causes toxoplasmosis in human and animal. in recent years, significant progress has been made in the identification of vaccine candidates which can induce protective responses. in this study we used complete rhoptry protein 2 gene of toxoplasma gondii as a single dna vaccine and evaluated its immune responses in comparison...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید