The purpose of this report is to describe the histopathology of radiolucent lesions associated with pulp necrosis in primary molars. Twenty-one carious, previously untreated, primary molars with radiolucent lesions were extracted with forceps under local anesthesia. If a lesion remained attached to the root, the specimen was transferred to 10% neutral buffered formalin. The sockets were gently ...

OBJECTIVE To determine the effects of autologous fibrinogen (AF) and absorbable barrier membrane (ABM) on periodontal healing of canine experimental grade-III furcation defects. ANIMALS 18 conditioned, laboratory-source, adult Beagles. PROCEDURE Defects were developed bilaterally at the second and fourth premolars and maintained for 12 weeks. Defects were treated with AF, ABM, AF and ABM, o...

* Post-Doctoral Student, Department of Microbiology, Dental Research Institute, São Leopoldo-Mandic. ** Professor and Chairman, Department of Oral Pathology, School of Dentistry, University of São Paulo. *** Doctor of Dental Medicine, Private Practice, Fairhope, USA. **** Professor and Chairman, Department of Periodontology, School of Dentistry, State University of Campinas. ***** Doctor of Den...

introduction: to describe the underlay tympanoplasty technique using an acellular dermal graft(alloderm) for tympanic membrane (tm) reconstruction in a guinea pig model and to demonstrate the feasibility of the technique using alloderm tissue harvested from the prepuce as a source of tissue for future grafting in human tm reconstruction.   materials and methods: the prepuce was divided during c...

OBJECTIVE Better understanding of the furcation anatomy may serve to decrease the risk of root perforation. The purpose of this study was to measure the thickness of root walls in the danger zone in mandibular first molars. MATERIALS AND METHODS The roots of 53 extracted human mandibular first molars were sectioned in the horizontal plane 4 mm below the orifice of the mesial and distal root c...

PURPOSE To evaluate the use of Portland cements with additives as furcation perforation repair materials and assess their biocompatibility. METHODS The four maxillary and mandibular premolars of ten male mongrel dogs (1-1.5 years old, weighing 10-15 kg) received endodontic treatment (n=80 teeth). The furcations were perforated with a round diamond bur (1016 HL). The perforations involved the ...

Molecular interactions between epithelium and mesenchyme are important for root formation. Nuclear factor I-C (Nfic) has been identified as a key regulator of root formation. However, the mechanisms of root formation and their interactions between Hertwig's epithelial root sheath (HERS) and mesenchyme remain unclear. In this study, we investigated the role of Nfic in root patterning and growth ...

This study aimed to observe the regenerative effect of brain-derived neurotrophic factor (BDNF) in a non-human primate furcation defect model. Class II furcation defects were created in the first and second molars of 8 non-human primates to simulate a clinical situation. The defect was filled with either, Group A: BDNF (500 µg/ml) in high-molecular weight-hyaluronic acid (HMW-HA), Group B: BDNF...

Objectives: To assess the relationships between the maxillary first molar and the maxillary sinus floor in a group of patients referred to a dental clinic. Methods: Ninety-seven patients were recruited for this study. The distances between the examined roots (mesio-buccal, disto-buccal and palatal) as well as furcations, and the sinus floor, were evaluated using cone beam computed tomography, a...