2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.

The selective ε-functionalization of 5-substituted furfurals via trienamine intermediates is reported herein. This methodology was successfully applied to several 5-substituted furfurals with different amines via formation of a trienamine through the furan ring. The rationalized reaction mechanism involves the addition of the trienamine intermediate to its corresponding iminium-ion producing ne...

Corroles and oxacorroles were synthesized by acid-catalyzed, 2+2 condensation. The condensation afforded different corroles bearing core-heteroatoms at the predesignated locations. Regioselective α-α’ linkage between pyrrole and furan or between pyrrole and pyrrole was achieved by keeping the linking carbon at different position of starting dipyrromethanes. The condensation was only fruitful wh...

A silicon carbide microtubular reactor has been used to measure branching ratios in the thermal decomposition of furan, C4H4O. The pyrolysis experiments are carried out by passing a dilute mixture of furan (approximately 0.01%) entrained in a stream of helium through the heated reactor. The SiC reactor (0.66 mm i.d., 2 mm o.d., 2.5 cm long) operates with continuous flow. Experiments were perfor...

In the title compound, C20H15BrO2S, the dihedral angle between the mean plane [r.m.s. deviation = 0.030 (2) Å] of the naphtho-furan ring system and the 4-methyl-phenyl ring is 38.49 (9)°. In the crystal, mol-ecules are linked by C-H⋯π and C-Br⋯π [3.871 (2) Å] inter-actions into stacks along the b-axis direction. These stacks are further linked by weak C-H⋯O hydrogen bonds, forming a three-dimen...

The title compound, C(10)H(6)O(4), lies across a twofold rotation axis through the midpoint of the C-C bond between the two carbonyl groups. The furan ring plane and the plane through all atoms are inclined at 23.88 (1)°. In the crystal structure, weak C-H⋯O hydrogen bonds form sheets in the bc plane and columns down the c axis.

In the title compound, C10H9NO3, the dihedral angle between the benzo-furan ring system (r.m.s. deviation for the non-H atoms = 0.009 Å) and the -C-C(O)-N- segment is 83.76 (1)°. In the crystal, mol-ecules are linked by N-H⋯O and O-H⋯O hydrogen bonds, generating (001) sheets, which feature C(4) and C(10) chains.

We have implemented our new procedure for computing Franck-Condon factors utilizing vibrational configuration interaction based on a vibrational self-consistent field reference. Both Duschinsky rotations and anharmonic three-mode coupling are taken into account. Simulations of the first ionization band of ClO(2) and C(4)H(4)O (furan) using up to quadruple excitations in treating anharmonicity a...

In the title compound, C(12)H(7)NO(5), the dihedral angle between the isoindole-1,3-dione plane and the least-squares plane of the furan ring is 89.2 (2)°. In the crystal structure, mol-ecules are linked through inter-molecular C-H⋯O hydrogen bonds, forming centrosymmetric dimers.