To cite: Cope TE, Baguley DM, Griffiths TD. Pract Neurol Published Online First: [please include Day Month Year] doi:10.1136/ practneurol-2014-001073 INTRODUCTION Disorders of audition stand at a crossroads between neurology, audiology, psychiatry and ENT. It is not uncommon for patients to ‘fall between the cracks’ of the referral pathway, and to become increasingly frustrated when specialties...

To investigate the difficulty that patients with Parkinson's disease (PD) have in performing fast movements, we used H(2)(15)O PET to study regional cerebral blood flow (rCBF) associated with performance of a simple predictive visuomanual tracking task at three different velocities. Tracking movements in PD patients (versus tracking with the eyes alone) were associated with a general underactiv...

Changes in dimensions of the ventricular chambers and the displacement of specific points on the wulls of the heart have been studied by the cinefluorographic technic. The contributions of the various myocardial layers to ventricular ejection have been considered in terms of the anatomic architecture of the heart. The mechanical effectiveness of myocardial contraction is closely related to the ...

Impulsive-compulsive disorders such as pathological gambling, hypersexuality, compulsive eating, and shopping are side effects of the dopaminergic therapy for Parkinson's disease. With a lower prevalence, these disorders also appear in the general population. Research in the last few years has discovered that these pathological behaviors share features similar to those of substance use disorder...

The classical brain-language model derived from the work of Broca, Wernicke, Lichtheim, Geschwind, and others has been useful as a heuristic model that stimulates research and as a clinical model that guides diagnosis. However, it is now uncontroversial that the classical model is (i) empirically wrong in that it cannot account for the range of aphasic syndromes, (ii) linguistically underspecif...

Recent research findings are incorporated in this review of the functional anatomy of the shoulder complex. The scapulothoracic mechanism is described, including a review of scapular motion and the structure and function of the sternoclavicular and acromioclavicular joints. New information regarding the resting position of the scapula on the thorax and the effect of aging and spinal posture on ...

The gluteal region was dissected in 18 adult cadavers. The attachments, directions, and orientations of the fibres of the tensor fasciae latae, gluteus medius, and gluteus minimus muscles were noted. The gluteus medius was found to be formed of three distinct parts, while the gluteus minimus was formed of two parts only; each part of these muscles had its separate innervations from the superior...

Transcriptional enhancers are a major class of functional element embedded in the vast non-coding portion of the human genome. Acting over large genomic distances, enhancers play critical roles in the tissue and cell type-specific regulation of genes, and there is mounting evidence that they contribute to the aetiology of many human diseases. Methods for genome-wide mapping of enhancer regions ...

The anatomic structures in the female that prevent incontinence and genital organ prolapse on increases in abdominal pressure during daily activities include sphincteric and supportive systems. In the urethra, the action of the vesical neck and urethral sphincteric mechanisms maintains urethral closure pressure above bladder pressure. Decreases in the number of striated muscle fibers of the sph...

fibers from the cochlea. Since both cochlear nuclei impinge upon cells in the SOC, it represents the initial site of binaural interaction. The SOC is so named because anatomically it is in a superior position relative to the inferior olivary complex. The term olivary is based on the olive-shaped protuberance on the ventral lateral surface of the medulla created by the underlying inferior olivar...