نتایج جستجو برای: fulvestrant

تعداد نتایج: 782  

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2014
S Noda Y Asano K Kurata T Morisaki S Kashiwagi H Kawajiri T Takashima N Onoda K Hirakawa

Aim: Fulvestrant (FUL) has been used to treat postmenopausal women with hormone receptor-positive metastatic or recurrent breast cancer after the failure of treatment attempts with tamoxifen (TAM) or aromatase inhibitor (AI). The factors predicting the outcome of treatment by FUL have not yet been identified. We retrospectively investigated our experience in an attempt to determine possible pre...

2012
Emily K Sims Sally Garnett Franco Guzman Françoise Paris Charles Sultan Erica A Eugster

UNLABELLED BACKGROUND McCune-Albright Syndrome (MAS) is usually characterized by the triad of precocious puberty (PP), fibrous dysplasia, and café au lait spots. Previous treatments investigated for PP have included aromatase inhibitors and the estrogen receptor modulator, tamoxifen. Although some agents have been partially effective, the optimal pharmacologic treatment of PP in girls with M...

Journal: :Molecular cancer therapeutics 2015
Ricardo Ribas Sunil Pancholi Stephanie K Guest Elisabetta Marangoni Qiong Gao Aurélie Thuleau Nikiana Simigdala Urszula M Polanska Hayley Campbell Aradhana Rani Gianmaria Liccardi Stephen Johnston Barry R Davies Mitch Dowsett Lesley-Ann Martin

PI3K/AKT/mTOR signaling plays an important role in breast cancer. Its interaction with estrogen receptor (ER) signaling becomes more complex and interdependent with acquired endocrine resistance. Targeting mTOR combined with endocrine therapy has shown clinical utility; however, a negative feedback loop exists downstream of PI3K/AKT/mTOR. Direct blockade of AKT together with endocrine therapy m...

Journal: :Onkologie 2010
Aude Féchon Jean-Pierre Droz

likely that the case report presented here can plead for a new prospective study on fulvestrant in CRPC. It is interesting to shortly review the major approaches for identifying new drugs with potential activity on hormone receptors in CRPC. The characteristic of CRPC is an overexpression of androgen receptors (AR) associated with different genetic modifications (AR mutation, for instance). One...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012
Amy M Fowler Szeman Ruby Chan Terry L Sharp Nicole M Fettig Dong Zhou Carmen S Dence Kathryn E Carlson M Jeyakumar John A Katzenellenbogen Robert D Schreiber Michael J Welch

UNLABELLED Estrogen receptor-α (ERα) and progesterone receptor (PR) are expressed in most human breast cancers and are important predictive factors for directing therapy. Because of de novo and acquired resistance to endocrine therapy, there remains a need to identify which ERα-positive (ERα(+))/PR-positive (PR(+)) tumors are most likely to respond. The purpose of this study was to use estrogen...

Journal: :Archives of otolaryngology--head & neck surgery 2011
Ameet Kamat Shilpi Rajoria Andrea George Robert Suriano Arulkumaran Shanmugam Uchechukwu Megwalu Pradeep Bangalore Prakash Raj Tiwari Stimson Schantz

OBJECTIVES To explore the induction of a proangiogenic phenotype in endothelial cells in the thyroid tumor microenvironment by estrogen-treated thyroid cancer cells and to define the role of vascular endothelial growth factor (VEGF) in this interaction. DESIGN Cell-based in vitro systems analysis. SUBJECTS Thyroid tumor cell lines (BCPAP [papillary thyroid cancer] and ML-1 [follicular thyro...

Journal: :Journal of the National Cancer Institute 2004
Jens Hoffmann Rolf Bohlmann Nikolaus Heinrich Helmut Hofmeister Jörg Kroll Hermann Künzer Rosemarie B Lichtner Yuki Nishino Karsten Parczyk Gerhard Sauer Hille Gieschen Hannes-F Ulbrich Martin R Schneider

BACKGROUND Antiestrogens of the selective estrogen receptor modulator (SERM) type, such as tamoxifen, have two major limitations: their mixed agonist and antagonist profile and the development of tumor resistance. We characterized two new pure antiestrogens-ZK-703 and ZK-253-that belong to the class of specific estrogen receptor destabilizers (SERDs), which includes fulvestrant, and compared th...

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