In a general fractional factorial design the n levels of each factor are coded by the n-th roots of the unity. This device allows a full generalization to mixed designs of the theory of polynomial indicator function already introduced for binary designs by Fontana and the Authors (2000). Properties of orthogonal arrays and regular fractions are discussed.

When fitting complex models, such as finite element or discrete event simulations, the experiment design should exhibit good properties of both projectivity and orthogonality. To reduce experimental effort, sequential design strategies allow experimenters to collect data only until some measure of prediction precision is reached. In this article, we present a batch sequential experiment design ...

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations was conducted using 6 sets of 2(4) full-factorial design based on four independent variables that were the number of hom...

We give a combinatorial interpretation for the super Catalan number S(m,m + s) for s ≤ 3 using lattice paths and make an attempt at a combinatorial interpretation for s = 4. We also examine the integrality of some factorial ratios.

In this study, the effects of some factors on bacterial growth and ferrous oxidation rates were investigated by Acidithiobacillus ferrooxidan in 250 ml shake flasks. One factor at a time (OFAT) design approach was used for preliminary evaluation of various factors affecting the process, such as pH, initial ferrous and elemental sulfur concentrations, shaker agitation rate, and liquid to flask v...

The effect of the Transcendental Meditation (TM) technique on working memory and field independence was investigated in a twelve-week longitudinal time-series study in which the uMatch Me" computerized memory game and the Rod and Frame Test were administered daily to a matched pair of 11-year-old boys and a matched pair of 14-year-old girls. One of the boys and one of the girls began the TM tec...

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the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

The present research concerns the formulation and evaluation of sustained release pellets filled capsule of opioid analgesic, Tramadol HCl. Development of sustained release dosage form is to maintain therapeutic blood levels of the drug for extended period of time. Sustained release formulation provides uniform concentration at absorption site, maintains plasma concentration within a therapeuti...

The purpose of the present research was to prepare and evaluate mannitol and cellulose based, directly compressible excipient using freeze-thawing technique. The mannitol to cellulose ratio (50:50, 60:40, and 70:30) and the rotation speed of propeller stirrer (200, 600, and 1000 rpm) were selected as independent variables in a 3 full factorial design. Water acted as a good medium for mannitol a...