cancer immunotherapy (passive or active) involves treatments which promote the ability of the immune system to fight tumor cells. several types of immunotherapeutic agents, such as monoclonal antibodies, immune checkpoint inhibitors, non-specific immunomodulatory agents, and cancer vaccines are currently under intensive investigation in preclinical and clinical trials. cancer vaccines induce pe...

Brucellosis, caused by the genus Brucella bacterium, is a well-known infection among domestic animals. Considering the serious economic and medical consequences of this infection, various preventive efforts have been made through using recombinant vaccines, based on outer membrane protein (OMP) antigens of Brucella species. The objective of the present study was to clone, analyze the sequence, ...

This paper presents a comparative research of low-power and high-speed full adder cells which are based on XOR-XNOR algorithm. The adder cells are decomposed into small modules and all of them have an in-depth analysis. Several designs of each of them are implemented, optimized, simulated and analyzed separately. We also design a novel XORXNOR module built upon bootstrapped pass transistor logi...

In this paper we introduced low leakage 10T one-bit full adders cells are proposed for mobile applications. The analysis has been performed on various process and circuits techniques, the analysis with leakage power. We introduced a new transistor resizing approach for 1bit full adder cells to determine the optimal sleep transistor size which reduce the leakage power and area to minimize leakag...

This paper presents a novel low-power majority function-based 1-bit full adder that uses MOS capacitors (MOSCAP) in its structure. It can work reliably at low supply voltage. In this design, the timeconsuming XOR gates are eliminated. The circuits being studied are optimized for energy efficiency at 0.18-mm CMOS process technology. The adder cell is compared with seven widely used adders based ...

The modulation of chromatin dynamics by ATP-dependent chromatin remodeling factors has been recognized as an important mechanism to regulate the balancing of self-renewal and pluripotency in embryonic stem cells (ESCs). Here we have studied the effects of a partial deletion of the gene encoding the chromatin remodeling factor Chd1 that generates an N-terminally truncated version of Chd1 in mous...

Background: The vascular response to recurrent tissue hypoxia and reperfusion following red blood cell sickling causes acute chest syndrome and chronic lung disease. The purpose of this study was to determine the pattern of chronic lung lesions and possible risk factors in sickle cell patients in lagos, Nigeria.Methods: From July 2012 to April 2013, Pulmonary function test (PFT) and chest-x-ray...

We introduce a full-field fluorescence imaging technique with axial confinement of about 100 nm at the sample/substrate interface. Contrary to standard surface imaging techniques, this confinement is obtained through emission filtering. This technique is based on supercritical emission selectivity. It can be implemented on any epifluorescence microscope with a commercial high numerical aperture...

This paper addresses the cell association problem in multi-tier in-band full-duplex (FD) networks. Specifically, we consider the case of decoupled cell association (DCA) in which users are not necessarily served by the same base station (BS) for uplink and downlink transmissions. Instead, users can simultaneously associate to different BSs based on two independent weighted path-loss cell associ...

Reprogramming somatic cells into a pluripotent state brings patient-tailored, ethical controversy-free cellular therapy closer to reality. However, stem cells and cancer cells share many common characteristics; therefore, it is crucial to be able to discriminate between them. We generated two induced pluripotent stem cell (iPSC) lines, with NANOG pre-transduction followed by OCT3/4, SOX2, and L...