Shankha Bhasma is a popular Ayurvedic formulation which is used in hyperacidity, indigestion, ulcerative dyspepsia and other acid peptic disorders. The dosage uniformity and patient compliance can be increased and adultration can be decreased in ayurvedic powders by formulating them into tablets. The aim of the present work is to develop and evaluate Shankha Bhasma tablets using starch and acac...

Pramipexole is the mostly prescribed drug in patients with Parkinson disease. The incidence of Parkinson disease is related to aging and mostly developed in elderly people with difficulty in swallowing or dysphagia. In the current study we aimed to develop an orally fast disintegrating tablet (ODT) of pramipexole as a preferable alternative in geriatric patients. Hence, the fast disintegration ...

Pioglitazone is an oral hypoglycemic drug, used for the treatment of type 2 diabetes. The main objectives this study were to improve aqueous solubility by preparing its solid dispersion fusion method using various carriers that will absorption and subsequent bioavailability. prepared tablets (TF1-TF5) evaluated parameters i.e.shape size, weight variation, hardness, friability, disintegration ti...

A case of a 40-year-old man with dehiscence of the prosthetic aortic valve and recurrence of mycotic aneurysm of the left ventricular outflow tract with osteogenesis imperfecta is presented. He had an operation of aortic valve replacement and direct closure of the mycotic aneurysm for infective endocarditis twenty-one months ago. We performed reoperation of prosthetic aortic valve, patch closur...

Ulcerative colitis is a disease of unknown aetiology characterized by friability of the colonic mucosa leading to ulceration. The clinical course is extremely varied, but is usually characterized by remissions and relapses. The initial attack carries the highest mortality rate. Medical treatment aims at supporting the patient over an attack until remission occurs. The use of cortisone or ACTH f...

The dual release system is used to achieve both quick and sustained release effect from dosage form. The dual release action achieve by using core compressed tablet, bi-layer or multi layer tablet, IR and SR granules containing matrix tablet and capsules. Some researcher formulated dual release system by incorporating disintegrants for immediate release part and different polymers for sustained...

ABSTRACT Sterculia gum is a complex polysaccharide of high molecular weight. The rapid swelling of gum particles, their relative insolubility and their unusual resistance to bacterial and enzymatic breakdown make this gum suitable as a bulk laxative. The present work deals with development of granular formulation using Sterculia gum and its evaluation. The evaluation includes size gradation usi...

Intra-cavitary thrombus size, mobility and friability are of great importance in deciding whether surgical removal is indicated. Thrombus characteristics may render surgical thrombectomy incomplete, a risk for catastrophic embolization. During de-airing of the heart, after removal of an intraventricular thrombus, filling the open ventricular cavity with blood serendipitously allowed trans-esoph...

Ventricular septal defect (VSD) is an uncommon but potentially deadly complication of transmural myocardial infarction (MI). Emergency surgical treatment has traditionally offered the best chance for survival. However, operative intervention is associated with high mortality and can be complicated by a recurrent VSD due to tissue friability around the infarcted area. Percutaneous catheter-based...

In the present study an attempt was made to formulate and evaluate Calcium and Vitamin K3 tablet using wet granulation technique incorporating various Excipients like Starch Powder, Starch Paste, Magnesium Sterate, Aerosil, Talc, Lactose, Vitamin K Liquid form and Water. The Formulated tablets were evaluated for different physicochemical properties like rheological properties, weight variation,...