Background & Aims: Tyrosinase is the most important enzyme in the production of pigments of the skin, eyes, and hair follicles. The enzyme is encoded by tyrosinase gene (TYR) or oculocutaneous albinism type 1A (OCA1A). Mutations in TYR gene result in pigmentation disorders such as albinism in humans. In view of the large number of mutations reported in this gene, the aim of this study was to id...

in this research, allele frequency and polymorphism of 27 microsatellite markers linked to gene loci controlling grain quality were determined between 47 rice varieties from four different groups including 21 iranian local, 16 improved, 7 irri and 3 upland rice varieties. average number of polymorphic information content (pic) and shannon’s diversity index were 0.54 and 1.14, respectively. maxi...

background: alzheimer's disease as a neurodegenerative disorder is the commonest type of dementia. a growing number of genes have been reported as the risk factors, which increase the susceptibility to alzheimer's disease. apolipoprotein e ( apoe) , which its ε4 allele has been reported as a risk factor in late onset alzheimer's disease (ad), is the main cholesterol carrier in the brain. the ma...

disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (bhmt) coding gene, leads to decrease in s-adenosyl methionine (sam) synthesis which takes part in dna methylation as a methyl donor. as a result, it can promote hypo-methylation of dna, chromosome instability, and chromosome missegregation, which in turn is one of t...

background: survival of the semi-allograft fetus during pregnancy opens a new area for the immunological based causes of recurrent spontaneous abortion (rsa). cytotoxic t lymphocyte-associated antigen 4 (ctla4) is a negative regulator of the t-cell activation, which may modulate peripheral self-tolerance of the allogeneic fetus. the present study aimed to investigate the +49 a/g ctla4 genetic p...