Prolidase is a cytosolic exopeptidase that cleaves iminodipeptides with carboxy-terminal proline or hydroxyproline and plays a major role in collagen turnover. Collagen is the essential content in atherosclerotic plaque, playing a key role in the stability/instability and progression of endothelial dysfunction in the pathogenesis of erectile dysfunction (ED). Consequently, in this study we soug...

The sulfhydryl group plays a role in the biological formation of melanin. Mechanisms suggested for the inverse relationship between the sulfhydryl group and the formation of melanin in mammalian skin include inhibition of tyrosinase and reaction with precursors of melanin (1, 2). However, knowledge in this field is fragmentary, and definitive proof of mechanism is lacking (3). The present work ...

The sulfhydryl group plays a role in the biological formation of melanin. Mechanisms suggested for the inverse relationship between the sulfhydryl group and the formation of melanin in mammalian skin include inhibition of tyrosinase and reaction with precursors of melanin (1, 2). However, knowledge in this field is fragmentary, and definitive proof of mechanism is lacking (3). The present work ...

several studies have shown that hepatocyte membrane composition changes in patients with cholestasis and cirrhosis. these alterations that are because of intracellular oxidative stress are supposed to be reflected in erythrocyte membrane. the aim of this study was to investigate the modification of erythrocyte membrane along with hexokinase and antioxidant enzymes during development of cirrhosi...

Summary Batter stabilisation presents a great challenge for gluten‐free (GF) bread, as CO 2 is released during bread‐making process, resulting in small, dense and crumbly breads. Apart from starch, protein plays crucial role gas cell stabilisation. This study aims to assess the effect of non‐gluten different sources (plant animal) on GF batter's rheological behaviour (pasting properties, rheolo...

As part of a detailed experimental study of the pathogenicity of disease of slate dust workers, the early biochemical changes in rat lung from 1 to 90 days after intratracheal inoculation of slate dust of particle size below 5 micron were investigated. A severalfold increase in free cell population (initially macrophages) was elicited by the dust. The free activity of acid phosphatase tended to...

Deficiency of dystrophin in skeletal muscles is supposed to be responsible for all the symptoms associated with Duchenne dystrophy (DMD) and Becker dystrophy (BMD). The dystrophin-deficient mdx mice, however, are clinically almost asymptomatic. Hence, other factor(s) might be responsible for the muscle pathology in DMD and BDM. As sulfhydryl groups are involved in maintaining the structure of m...

Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they can be either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell ag...

Oxidative stress is a recognized factor of ischemia reperfusion injury. It shares damage of lipids (LPO) and proteins (PPO), and consequently might cause changes in activity of transport systems. Global 15 min ischemia followed by 2, 24 and 48 hour reperfusion was induced by four-vessel occlusion in Wistar rats of both sexes. Levels of TBARS and conjugated dienes as parameters of LPO were analy...