Fluoride is a ubiquitous natural substance that is often used in dental products to prevent dental caries. The biphasic actions of fluoride imply that excessive systemic exposure to fluoride can cause harmful effects on embryonic development in both animal models and humans. However, insufficient information is available on the effects of fluoride on human embryonic stem cells (hESCs), which is...

PURPOSE Ductal lavage has been used for risk stratification and biomarker development and to identify intermediate endpoints for risk-reducing intervention trials. Little is known about patient characteristics associated with obtaining nipple aspirate fluid (NAF) and adequate cell counts (> or =10 cells) in ductal lavage specimens from BRCA mutation carriers. METHODS We evaluated patient char...

Non-Adjacent Form (NAF) is a canonical form of signed binary representation of integers. We present some explicit formulae of NAF and its left-to-right analogue (FAN) for randomly chosen n-bit integers. Interestingly, we prove that the zero-run length appeared in FAN is asymptotically 16/7, which is longer than that of the standard NAF. We also apply the proposed formulae to the speed estimatio...

Mold powders in continuous casting of steel contain fluorine through mainly CaF2 and occasionally NaF and Na3AlF6. Fluorine develops dangerous gases such as SiF4 and HF at high temperatures. In this study, CaF2 is partly replaced by substances such as Na2CO3, ZnO and Fe2O3.Sulfur free Portland cement clinker containing gypsum was used as a new product base. These additions developed comparable ...

UNLABELLED In a national prospective registry, we previously studied the impact of (18)F-sodium fluoride PET (NaF PET) on the intended management of cancer patients with osseous metastases. The clinical impact of NaF PET for monitoring the response to systemic therapies in such patients is unknown. The objective of this study was to assess the impact of NaF PET results obtained for treatment mo...

Fluoride is an essential trace element but also an environmental contaminant with major sources of exposure being drinking water, food and pesticides. Previous studies showed that sodium fluoride (NaF) at 5 mM or more is required to induce apoptosis and chromosome aberrations and proposed that DNA damage and apoptosis play an important role in toxicity of excessive fluoride. The aim of this stu...

BACKGROUND Protein carbonyl levels are the most frequently used biomarker of protein oxidation in several human diseases, including cancer. Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium from which nipple aspirate fluid can be collected and analysed to assess tissue metabolic activity. Our aims were to perform an exploratory investigation o...

The objective of this study was to investigate the toxic effects of different concentrations of sodium fluoride (200, 400 and 600 ppm NaF), administered in drinking water for 30 days, on the reproductive system of adult female Sprague-Dawley rats. The rats in the two higher-dosed groups showed clinical signs of toxicity unlike those exposed to NaF at a concentration of 200 ppm. Ingestion of 200...

s 47 Fluoride 36 (1) 2003 control (group 2). Administration of either vitamins C (50 mg/kg body weight/day), D (2 ng/0.2 mL olive oil/animal/day) or a combination of vitamins C+D+E along with NaF caused significant amelioration in body weight and feed consumption, as well as glucose, protein, sodium and potassium concentrations in the serum of Pand F(1)-generation rats compared with the NaF-onl...

In addition to mitochondria, BCL-2 is located at the endoplasmic reticulum (ER) where it is a constituent of several distinct complexes. Here, we identify the BCL-2-interacting protein at the ER, nutrient-deprivation autophagy factor-1 (NAF-1)-a bitopic integral membrane protein whose defective expression underlies the aetiology of the neurodegenerative disorder Wolfram syndrome 2 (WFS2). NAF-1...