Osteoporosis & bone fragility Every second woman and every fifth man aged 50 years or over sustains a fragility fracture (vertebral, hip, wrist or proximal humerus facture) during the rest of their lifetime [1]. Fractures virtually always lead to temporary morbidity, and with age, the likelihood of permanent and more severe comorbidities markedly increases [2]. For example, of those who sustain...

The present study aimed to evaluate the effect of chronic co-exposure to chlorpyrifos (CPF) and deltamethrin (DLT) on erythrocyte osmotic fragility, lipid peroxidation and the ameliorative effect of alpha-lipoic acid (ALA) on erythrocyte fragility. Thirty-six male Wistar rats divided into six groups of six rats each were used for the study. Groups I (S/oil) and II (ALA) were given soya oil (2 m...

BACKGROUND The presence of a fragility fracture is a major risk factor for osteoporosis, and should be an indicator for osteoporosis diagnosis and therapy. However, the extent to which patients who fracture are assessed and treated for osteoporosis is not clear. METHODS We performed a review of the literature to identify the practice patterns in the diagnosis and treatment of osteoporosis in ...

With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem. Osteoporotic fragility fractures affect the quality of life and are associated with premature mortality. The magnitude of the disease may become larger in developing countries, particularly in the Middle East where the prevalence of low bone mass is higher than in Western countries. Besides two small...

BACKGROUND hip fractures are an increasing source of morbidity and mortality in older people. The role of visual function tests such as visual impairment, stereopsis, contrast sensitivity and visual field defects in low fragility hip fractures in Asian populations is not well understood. OBJECTIVE to determine the association between various visual function tests and low fragility hip fractur...

FRAXA is one of a number of fragile sites in human chromosomes that are induced by agents like fluorodeoxyuridine (FdU) that affect intracellular thymidylate levels. FRAXA coincides with a >200 CGG*CCG repeat tract in the 5' UTR of the FMR1 gene, and alleles prone to fragility are associated with Fragile X (FX) syndrome, one of the leading genetic causes of intellectual disability. Using siRNA ...

With the increasing life expectancy, osteoporosis is becoming a major worldwide health problem. Osteoporotic fragility fractures affect the quality of life and are associated with premature mortality. The magnitude of the disease may become larger in developing countries, particularly in the Middle East where the prevalence of low bone mass is higher than in Western countries. Besides two small...

British Journal of General Practice, December 2012 667 INTRODUCTION Fragility fractures result from mechanical forces that would not ordinarily result in fracture. The World Health Organization (WHO) has quantified this as forces equivalent to a fall from a standing height or less. Reduced bone density is a major risk factor for fragility fractures. The prevalence of osteoporosis increases mark...

Cells can maintain their functions despite fluctuations in intracellular parameters, such as protein activities and gene expression levels. This commonly observed biological property of cells is called robustness. On the other hand, these parameters have different limitations, each reflecting the property of the subsystem containing the parameter. The budding yeast cell cycle is quite fragile u...

The main HIV co-morbidities include coronary heart disease (CHD), metabolic syndrome and lipodystrophy, renal impairment, fragility fractures, neurocognitive disease, and the emerging complications of insulin resistance and fragility fractures. The evidence base for toxicities seen with ART is gained mainly from comparative efficacy studies of ART regimens, where toxicity is not the primary end...