The aim of this study is to clarify the effect of low intensity pulsed ultrasound (LIPUS) on shortening of the fracture healing period and endochondral ossification during the fracture healing process. We first established a model of aging-related delayed union fractures consisting of aged mouse (C57BL/6J; 40 weeks old) with closed femur fractures. We compared the healing process of 40-week-old...

Low-magnitude high-frequency vibration (LMHFV) has been proven to promote osteoporotic fracture healing. Mechanical stimulation was reported to enhance SDF-1/CXCR4 signalling in mesenchymal stem cells (MSCs). We hypothesised that LMHFV promoted osteoporotic fracture healing by enhancing MSC migration through the SDF-1/CXCR4 pathway. 152 ovariectomised SD-rats received closed femoral fracture in...

Correction: Time Course of 25(OH)D 3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral denisty (BMD) " Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD) " [1], the last name of Christoph Wölfl was incorrectly spelt as Wöfl. I...

OBJECTIVE To determine the surgical outcome of patients with axial cervical spine fractures. METHODS The randomised double-blinded placebo-controlled clinical study was conducted at the Indus Hospital, Karachi, from August 2011 to August 2013. Patients were randomised to receive placebo or strontium ranelate postoperatively after surgical fixation of tibial diaphyseal fractures. Assessment of...

Despite the growing knowledge on the mechanisms of fracture healing, delayed healing and non-union formation remain a major clinical challenge. Animal models are needed to study the complex process of normal and impaired fracture healing and to develop new therapeutic strategies. Whereas in the past mainly large animals have been used to study normal and impaired fracture healing, nowadays rode...

abstract non-:union: occurs when bone healing ceases and does not continue without some type of intervention. classification of non-:union: is traditionally based on the amount of callus or bone healing at the fracture site. successful treatment of non-:union: often depends on appropriate reduction and realignment of the fracture, bone grafting if necessary, and stabilization. this may not be p...

For the first time, repeatable self-healing was achieved in a cross-linked epoxy polymer by incorporating 2-ethyl-4-methylimidazole (24-EMI) into the matrix as a latent polymerization initiator. Upon material damage and infiltration of liquid EPON 8132 epoxy monomer healing agent into the crack plane, polymerization occurs in the damaged region with a moderate application of heat in the presenc...

INTRODUCTION: It is common knowledge that the fracture healing process is strongly influenced by the mechanical behaviour of the bone implant complex (BIC) due to the resulting interfragmentary movement (IFM) of the bone fragments at the fracture site. Unreamed intramedullary nailing reduces the disturbance of blood supply in comparison to reamed nailing but leads to a more flexible stabilizati...

BACKGROUND Despite the prominence of hip fractures in orthopedic trauma, the assessment of fracture healing using radiographs remains subjective. The variability in the assessment of fracture healing has important implications for both clinical research and patient care. With little existing literature regarding reliable consensus on hip fracture healing, this study was conducted to determine i...

RATIONALE Fracture nonunion is a great challenge for orthopedic surgeons. Many surgical interventions are associated with significant pain and heavy economic burden. Therefore, our aim was to evaluate the outcomes of a new nonoperative treatment for fracture nonunion. PATIENT CONCERNS A 44-year-old man suffered closed fractures of the right tibia and left femur. Eleven months after surgery, t...