نتایج جستجو برای: foxo1

تعداد نتایج: 2363  

Journal: :The EMBO journal 2010
Wuqiang Fan Hidetaka Morinaga Jane J Kim Eunju Bae Nathanael J Spann Sven Heinz Christopher K Glass Jerrold M Olefsky

The macrophage-mediated inflammatory response is a key etiologic component of obesity-related tissue inflammation and insulin resistance. The transcriptional factor FoxO1 is a key regulator of cell metabolism, cell cycle and cell death. Its activity is tightly regulated by the phosphoinositide-3-kinase-AKT (PI3K-Akt) pathway, which leads to phosphorylation, cytoplasmic retention and inactivatio...

2013
Loredana Fiorentino Michele Cavalera Stefano Menini Valentina Marchetti Maria Mavilio Marta Fabrizi Francesca Conserva Viviana Casagrande Rossella Menghini Paola Pontrelli Ivan Arisi Mara D'Onofrio Davide Lauro Rama Khokha Domenico Accili Giuseppe Pugliese Loreto Gesualdo Renato Lauro Massimo Federici

ADAM17 and its inhibitor TIMP3 are involved in nephropathy, but their role in diabetic kidney disease (DKD) is unclear. Diabetic Timp3(-/-) mice showed increased albuminuria, increased membrane thickness and mesangial expansion. Microarray profiling uncovered a significant reduction of Foxo1 expression in diabetic Timp3(-/-) mice compared to WT, along with FoxO1 target genes involved in autopha...

Journal: :Journal of lipid research 2013
Sasmita Tripathy Donald B Jump

Elevated hepatic expression of fatty acid elongase-5 (Elovl5) induces FoxO1 phosphorylation, lowers FoxO1 nuclear content, and suppresses expression of genes involved in gluconeogenesis (GNG). In this report, we define the molecular and metabolic basis of Elovl5 control of FoxO1 phosphorylation. Adenoviral-mediated (Ad-Elovl5) induction of hepatic Elovl5 in diet-induced obese, glucose-intoleran...

2013
Nirmala Hariharan Yoshiyuki Ikeda Chull Hong Ralph R. Alcendor Soichiro Usui Shumin Gao Yasuhiro Maejima Junichi Sadoshima

Autophagy is a bulk degradation mechanism for cytosolic proteins and organelles. The heart undergoes hypertrophy in response to mechanical load but hypertrophy can regress upon unloading. We hypothesize that autophagy plays an important role in mediating regression of cardiac hypertrophy during unloading. Mice were subjected to transverse aortic constriction (TAC) for 1 week, after which the co...

Journal: :American journal of physiology. Cell physiology 2009
Thomas J McLoughlin Sierra M Smith Alissa D DeLong Hengbing Wang Terry G Unterman Karyn A Esser

Recent studies indicate that FoxO transcription factors play an important role in promoting muscle atrophy. To study mechanisms mediating effects of FoxO proteins on muscle wasting, FoxO1-estrogen receptor fusion proteins that are activated by treatment with 4-hydroxytamoxifen (4-OH-T) were stably transfected in C(2)C(12) skeletal myoblasts using the pBABE retroviral system and grown into multi...

2013
Xiaojun Liu Ying Cui Meixia Li Haifeng Xu Jin Zuo Fude Fang Yongsheng Chang

BACKGROUND Reactive oxygen species arise in the mitochondria as byproducts of respiration and oxidase activity and have important roles in many physiological and pathophysiological conditions. The level of reactive oxygen species is regulated by a number of enzymes and physiological antioxidants, including HO-1, Sod2, catalase and COX-2, etc. And HO-1 against oxidative stress requires an increa...

Journal: :The Biochemical journal 2004
Xiangshan Zhao Lixia Gan Haiyun Pan Donghui Kan Michael Majeski Stephen A Adam Terry G Unterman

FOXO1, a Forkhead transcription factor, is an important target of insulin and growth factor action. Phosphorylation of Thr-24, Ser-256 and Ser-319 promotes nuclear exclusion of FOXO1, yet the mechanisms regulating nuclear/cytoplasmic shuttling of FOXO1 are poorly understood. Previous studies have identified an NLS (nuclear localization signal) in the C-terminal basic region of the DBD (DNA-bind...

2016
Asako Kinoshita Lena Locher Reka Tienken Ulrich Meyer Sven Dänicke Jürgen Rehage Korinna Huber Martin Young

Forkhead box protein O1 (FoxO1) is a transcription factor which promotes hepatic glucose production (HGP) by up-regulating the transcription of gluconeogenic enzymes in monogastric species. The activity of FoxO1 is inhibited by insulin-induced phosphorylation. The aims of the present study were to find associations between FoxO1 expression and variables associated with HGP as affected by feedin...

Laleh Behboudi, Masoomeh Yarmohammadi, Mojtaba Eizadi,

Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ ...

Objective(s): Non-small cell lung cancer (NSCLC) has become a serious global health problem in the 21st century, and tumor proliferation and metastasis are the leading causes of death in patients  with lung cancer. The present study aimed to verify the function of miR-96 and miR-96 in relation to competing with endogenous RNA regulatory network in NSCLC progression inc...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید