The objective of this study was to explore the optimal combination of agents used along with cisplatin for protection of hepatotoxicity. Animal experiment was carried out based on the orthogonal design L(8) (2(7)) setting seven factors with two different levels of each, and eight groups of mice were needed. The agents tested in this study were zinc, selenium, fosfomycin, sodium thiosulfate (STS...

Objectives: To determine the frequency of Escherichia coli (E. Coli) with multi-drug resistance and sensitivity to oral Fosfomycin in urinary tract infections a public sector hospital Peshawar Pakistan. Material Methods: A descriptive cross-sectional study convenient consecutive sampling technique at Department Medicine Khyber Teaching Hospital Peshawar. total 179 patients were recruited curren...

Flucloxacillin, fosfomycin, fusidic acid, teichomycin, and vancomycin were tested against 50 clinical isolates of methicillin-resistant Staphylococcus aureus by a broth macrodilution technique. Teichomycin had a narrow range of activity, similar to that of vancomycin (0.5 to 2.0 micrograms/ml). Fusidic acid had the lowest range of inhibitory activity, with 50 and 90% MICs of 0.19 and 0.35 micro...

Synergy was evident in zones of inhibition between neighboring filter discs containing fosfomycin and an unidentified fermentation broth placed on the surface of agar growth medium seeded with Bacillus megaterium (S. Mochales ; personal communication). The antibiotic was isolated and identified as arenaemycin (T. Miller and K. Wilson; personal communication). We report in this communication tha...

Objective: To determine efficacy of fosfomycin in urinary tract infections occurring during pregnancy. Study Design: Descriptive study. Settings: Obstetrics & Gynecology Ward Dow University OJHA Campus, Karachi. Duration Study: 11-08-2021 till 12-02-2022 Subject and Methods: Total 147 pregnant women presented with were enrolled. Detailed demographics recorded after taking informed written c...

The in vitro activity of imipenem in combination with fosfomycin against 17 clinical isolates of methicillin-resistant Staphylococcus aureus from hospitalized patients was investigated by checkerboard and time-kill studies. Of the 17 strains tested, checkerboard studies revealed synergy in 14(82.3%)and indifference in 3(17.6%): the time-kill studies also revealed synergy in 14 of 14 strains at ...

An increase in extended-spectrum-lactamase (ESBL)-producing Escherichia coli has been observed in outpatient settings. Consequently, 100 ESBL-positive E. coli isolates from ambulatory patients with clinically confirmed urinary tract infections were collected by a single laboratory between October 2004 and January 2008. Antimicrobial susceptibility testing was carried out using the oral antibiot...

A HPLC-MS/MS method, which was suitable to be used in withdrawal time studies, was validated for the determination of fosfomycin in swine muscle, liver, kidney and skin-fat. Therefore, the withdrawal time of fosfomycin in swines, considering a MRL of 0.5 μg/mL was studied. Forty-eight pigs were assigned to two groups; in group one, fosfomycin was orally administered daily with 30 mg⁄kg bw and t...

Respiratory diseases are one of the most important problems in modern intensive swine production (Gardner and Hird, 1990). These diseases are a common cause of morbidity and mortality in weaning pigs (Gardner and Hird, 1990; Galina et al., 1994; Dos̆en et al., 2007). The concentrations of antibiotics in epithelial lining fluid (ELF) reflect the antimicrobial activity for extracellular pathogens ...