In addition, there was a typographical error in the Abstract. " Inhibition of p38 MAPK by SB023580 or pERK by U0126 abolished the proliferation and up-regulatory effects of irisin on Runx 2 expression and ALP activity. " now reads " Inhibition of p38 MAPK by SB203580 or pERK by U0126 abolished the proliferation and up-regulatory effects of irisin on Runx 2 expression and ALP activity. " These e...

It was with great interest that I read the article, entitled “Serum Irisin Level Can Predict the Severity of Coronary Artery Disease in Patients with Stable Angina,” published in the Korean Circulation Journal,1) a leading journal in cardiology and cardiac surgery. I would like to congratulate Efe et al.1) on their contributions to our knowledge of the circulatory physiology and biochemistry of...

Background Exercise stimulates the production of fibronectin type III domain-containing protein 5 (FNDC5), which is cleaved to release a protein called irisin. This protein induces browning of white adipose tissue resulting in increased thermogenesis. Different studies have measured circulating irisin at baseline and in response to exercise among a wide variety of individuals; yet, regarding th...