نتایج جستجو برای: fluoxetine

تعداد نتایج: 3720  

2016
Stephanie Pope Solomon G Zaraa

BACKGROUND Previous literature has found fluoxetine to be relatively safe in overdose. This study hopes to examine this idea along with support from published pharmacokinetic information including serum fluoxetine and norfluoxetine levels based on information from a clinical case series. METHODS Four cases are presented along with vital abnormalities, electrocardiogram abnormalities, and phys...

2016
Ramon Guirado Danilo La Terra Mathieu Bourguignon Hector Carceller Juzoh Umemori Pia Sipilä Juan Nacher Eero Castrén

Neuronal plasticity peaks during critical periods of postnatal development and is reduced towards adulthood. Recent data suggests that windows of juvenile-like plasticity can be triggered in the adult brain by antidepressant drugs such as Fluoxetine. Although the exact mechanisms of how Fluoxetine promotes such plasticity remains unknown, several studies indicate that inhibitory circuits play a...

Journal: :Anais da Academia Brasileira de Ciencias 2015
Natasa Spasojevic Predrag Jovanovic Sladjana Dronjak

We have recently shown that chronic fluoxetine treatment acted significantly increasing plasma norepinephrine and epinephrine concentrations both in control and chronically stressed adult male rats. However, possible effects of fluoxetine on catecholamine synthesis and re-uptake in adrenal medulla have been largely unknown. In the present study the effects of chronic fluoxetine treatment on tyr...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
R Ranganathan E R Sawin C Trent H R Horvitz

We isolated two mutants defective in the uptake of exogenous serotonin (5-HT) into the neurosecretory motor neurons of Caenorhabditis elegans. These mutants were hypersensitive to exogenous 5-HT and hyper-responsive in the experience-dependent enhanced slowing response to food modulated by 5-HT. The two allelic mutations defined the gene mod-5 (modulation of locomotion defective), which encodes...

Journal: :Biological & pharmaceutical bulletin 2011
Ju-Young Park Seung-Woo Kim Ja-Kyeong Lee Weon Bin Im Byung Kwan Jin Sung-Hwa Yoon

A series of fluoxetine, where the N-methylamino group was replaced and then simplified, were synthesized and their inhibitory effect was tested for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in lipopolysaccharide (LPS)-induced BV2 cells. Although the synthesized compounds generally revealed weaker activity or greater cytotoxicity than fluoxetine, compound 10a, in w...

Journal: :The American journal of physiology 1999
Helen L Reeve Daniel P Nelson Stephen L Archer E Kenneth Weir

The anorexic agents dexfenfluramine and fenfluramine plus phentermine have been associated with outbreaks of pulmonary hypertension. The fenfluramines release serotonin and reduce serotonin reuptake in neurons. They also inhibit potassium current ( I K), causing membrane potential depolarization in pulmonary arterial smooth muscle cells. The recent withdrawal of the fenfluramines has led to the...

Journal: :Arteriosclerosis and thrombosis : a journal of vascular biology 1993
S L Sigal J Gellman G M Anderson L D True Q Chen M J Tselentakis F S Ling M D Ezekowitz

There is evidence that angioplasty-induced vasospasm is mediated by serotonin (5-hydroxytryptamine [5-HT]) release from platelets. We tested the hypothesis that pretreatment of the atherosclerotic rabbit with fluoxetine, a platelet-uptake inhibitor of 5-HT, would reduce vasospasm after balloon angioplasty. Short-term administration of fluoxetine reduced platelet 5-HT uptake to 4% of baseline. D...

Journal: :Journal of clinical psychopharmacology 1998
J Zajecka J Fawcett J Amsterdam F Quitkin F Reimherr J Rosenbaum D Michelson C Beasley

Selective serotonin reuptake inhibitors may be associated with new adverse events after abrupt discontinuation. Hypothesizing that the long half-life of fluoxetine would be protective, this study analyzed the effects of abrupt fluoxetine discontinuation during a randomized, double-blind, placebo-controlled study of depression maintenance treatment. After 12 weeks of fluoxetine treatment (20 mg/...

Journal: :Journal of the American Academy of Child and Adolescent Psychiatry 2003
Boris Birmaher David A Axelson Kelly Monk Catherine Kalas Duncan B Clark Mary Ehmann Jeffery Bridge Jungeun Heo David A Brent

OBJECTIVE To assess the efficacy and tolerability of fluoxetine for the acute treatment of children and adolescents with generalized anxiety disorder, separation anxiety disorder, and/or social phobia. METHOD Anxious youths (7-17 years old) who had significant functional impairment were randomized to fluoxetine (20 mg/day) (n = 37) or placebo (n = 37) for 12 weeks. RESULTS Fluoxetine was ef...

2017
Kentaro Miyamoto Bisei Ohkawara Mikako Ito Akio Masuda Akihiro Hirakawa Tadahiro Sakai Hideki Hiraiwa Takashi Hamada Naoki Ishiguro Kinji Ohno

Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA. We introduced the TOPFlash reporter plasmid into HCS-2/8 human chondrosarcoma cells to estimate the Wnt/β-catenin activity in the presence of 10 μ...

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