The effects of an overlapping stenosis on blood flow characteristics in a narrow artery have been investigated. To account for the non-Newtonian behavior, blood has been represented by a Casson fluid. The equation describing the flow has been solved and the expressions for the flow characteristics, namely, the impedance, the wall shear stress, the shear stress at the stenosis throats and the sh...

Immunofluorescence microscopy was used to determine the number of endothelial cells with stress fibers for three age groups, and for three distinct anatomical locations within the descending thoracic aorta of both normotensive and spontaneously hypertensive rats. For each age group examined, hypertensive rats consistently demonstrated greater stress fiber expression than did normotensive rats. ...

The behaviour of viscoplastic drops during formation and detachment from a capillary nozzle, free-fall, impact on a solid substrate and subsequent spreading are investigated experimentally by high-speed imaging. Drop dynamic behaviour is an integral component of many contemporary industrial processes ranging from fuelinjection systems in combustion engines to spray coating, agrochemical and pha...

In this study the pressure-drop, mean and rms axial velocity data are measured using a differential pressure transducer and a laser Doppler anemometer for the flow of Newtonian and non-Newtonian fluids in a concentric annular pipe (radius ratio =0.5) at various Reynolds numbers encompassing the laminar, transitional and turbulent regimes. Three different fluids are utilized; a semi-rigid shear-...

We have studied the flow induced by a macroscopic spherical particle settling in a Laponite suspension that exhibits a yield-stress, thixotropy and shear-thinning. We show that the fluid thixotropy (or aging) induces an increase with time of both the apparent yield stress and shear-thinning properties but also a breaking of the flow fore-aft symmetry predicted in Hershel-Bulkley fluids (yield-s...

Background Mechanical stress is a primary determinant of bone growth and remodeling: weight bearing and locomotion stimulate interstitial fluid flow through the bone canalicular system, and the resultant shear stress is a major mechanism whereby mechanical forces stimulate bone growth [1]. In response to fluid shear stress and other types of mechanical stimulation, osteoblasts produce large amo...

High levels of fluid shear stress at the blood vessel wall directly stimulate von Willebrand factor (vWF)-mediated platelet adhesion and aggregation and thereby contribute to the pathogenesis of arterial thrombosis. We have found that a pathological level of arterial wall shear stress (90 dynes/cm2) induces platelet aggregation that is associated with the phosphorylation of pleckstrin, a M(r) 4...

A mathematical analysis has been presented to study the effect of a mild stenosis on blood flow characteristics with the representation of blood by couple stress fluid. The equations governing the flow of the proposed model are solved and closed form expressions for the blood flow characteristics, namely, dimensionless resistance to flow and wall shear stress at maximum height of the stenosis a...

Metastasis contributes to over 90% of cancer-related deaths and is initiated when cancer cells detach from the primary tumor, invade the basement membrane, and enter the circulation as circulating tumor cells (CTCs). While metastasis is viewed as an inefficient process with most CTCs dying within the bloodstream, it is evident that some CTCs are capable of resisting hemodynamic shear forces to ...

Once plaques intrude into the lumen, the shear stress they are exposed to alters with hitherto unknown consequences for plaque composition. We investigated the relationship between shear stress and strain, a marker for plaque composition, in human coronary arteries. We imaged 31 plaques in coronary arteries with angiography and intravascular ultrasound. Computational fluid dynamics was used to ...