BACKGROUND Collagen is the most abundant protein in animals. Each polypeptide chain of collagen is composed of repeats of the sequence: Gly-X-Y, where X and Y are often L-proline (Pro) and 4(R)-hydroxy-L-proline (Hyp) residues, respectively. These chains are wound into tight triple helices of great stability. The hydroxyl group of Hyp residues contributes much to this conformational stability. ...

The Gal4/ UAS binary method is powerful for gene and neural circuitry manipulation in Drosophila. For most neurobiological studies, however, Gal4 expression is rarely tissue-specific enough to allow for precise correlation of the circuit with behavioral readouts. To overcome this major hurdle, we recently developed the FINGR method to achieve a more restrictive Gal4 expression in the tissue of ...

In Streptococcus gordonii DL1, inactivation of the ccpA gene and a gene encoding an Fnr-like protein (Flp) demonstrated that CcpA was essential for carbohydrate catabolite repression and that Flp was required for optimal expression and anaerobic induction of the arginine deiminase system.

Entomopathogenic nematodes (EPNs) employ a sophisticated chemosensory apparatus to detect potential hosts. Understanding the molecular basis of relevant host-finding behaviours could facilitate improved EPN biocontrol approaches, and could lend insight to similar behaviours in economically important mammalian parasites. FMRFamide-like peptides are enriched and conserved across the Phylum Nemato...

BACKGROUND Lung cancer is one of the leading causes of cancer-related mortality worldwide. Conventional chemotherapy and radiotherapy are the primary therapeutic methods for lung cancer with the use of combination therapies gaining popularity. The frequency and duration of treatment, as well as, managing lung cancer by targeting multiple aspects of cancer biology is often limited by toxicity to...

During a search for conditions appropriate for Pt-catalyzed CO reduction using dihydrogen directly, metal-free conditions were discovered instead. A bulky, strong phosphazene base forms a "frustrated" Lewis pair (FLP) with a trialkylborane in the secondary coordination sphere of a rhenium carbonyl. Treatment of the FLP with dihydrogen cleanly affords multiple hydride transfers and C-C bond form...

BACKGROUND Though there has been profound research on the curious change in correlation between total fertility rate (TFR) and female labor force participation (FLP) in the mid-1980s, aspects of the compositional character of age-specific effects and the nature of countries’ heterogeneity have been neglected. OBJECTIVE The present paper aims to contribute to filling this gap by analyzing annual...

Forum lingkar pena (FLP) didirikan oleh pesantren Darul Ulum agar para santri melek literasi dan nomerasi, tidak hanya cerdas soal ilmu agama, melainkan juga secara sosial. Focus penelitian ini adalah kegiatan FLP, bentuk digital yang diterapkan, tantangan serta solusi dalam menerapkan digital. Metode menggunakan kualitatif dengan jenis purposif sumpling pengambilan data. Pengumpulan data tekni...

Introdução: fissura labiopalatina (FLP) trata-se de malformação congênita orofacial, com grande incidência e etiologia multifatorial, sendo, em geral, classificada três grupos, afetando: apenas lábio; palato; lábio palato. Objetivo: analisar o que a literatura fonoaudiológica apresenta sobre achados referentes funções orofaciais diferentes tipos labiopalatina. Métodos: realizada revisão acerca ...