The goal of this study was to examine the role of mTOR complex 2 (mTORC2) as a therapeutic target in ovarian clear cell carcinoma (CCC), which is regarded as an aggressive, chemoresistant histologic subtype. Using tissue microarrays of 98 primary ovarian cancers [52 CCCs and 46 serous adenocarcinomas (SAC)], activationofmTORC2wasassessedby immunohistochemistry.Then, thegrowth-inhibitory effecto...

Cytokine expression in a tumor microenvironment can impact both host defense against the tumor and tumor cell survival. In this study, we sought to clarify whether the cytokine gene expression profile could have clinical associations with ovarian cancer. We analyzed the expression of 16 cytokine genes (IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p35, IL-12p40, IL-15, IFN-γ, TNF-α, IL-6, H...

Preparata and Vuillemin proposed the cube-connected cycles (CCC) in 1981 16], and in the same paper, gave an asymptotically-optimal layout scheme for the CCC. We give a new layout scheme for the CCC which requires less than half of the area of the Preparata-Vuillemin layout. We also give a non-trivial lower bound on the layout area of the CCC. There is a constant factor of 2 between the new lay...

ÐPreparata and Vuillemin proposed the cube-connected cycles (CCC) and its compact layout in 1981 [17]. We give a new layout of the CCC which uses less than half the area of the Preparata-Vuillemin layout. We also give a lower bound on the layout area of the CCC. The area of the new layout deviates from this bound by a small constant factor. If we aunfoldo the cycles in the CCC, the resulting st...

Many collaborative multi-robot application domains have limited areas of operation that cause spatial conflicts between robotic teammates. These spatial conflicts can cause the team’s productivity to drop with the addition of robots. This phenomenon is impacted by the coordination methods used by the team-members, as different coordination methods yield radically different productivity results....

Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs. CCC DNA is converted from a relaxed circular (RC) DNA in the virion early during infection as well as from RC DNA in intracellular progeny nucleocapsids via an intracellular amplification pathway. Curre...

OBJECTIVE The heterogeneity in the degree of collateralization among patients with coronary artery disease (CAD) remains incompletely understood. We evaluated the predictors of poorly developed coronary collateral circulation (CCC) in patients with stable coronary artery disease. METHODS Current study is a retrospective study, consisting of 118 patients with poor CCC and 130 patients with goo...

BACKGROUND Cholangiocarcinoma (CCC) is the second most common type of primary liver cancer, and is associated with a high rate of mortality due to the difficulty of early detection and resistance to chemotherapeutic agents. To evaluate the possibility for new therapeutic strategies, we examined the combined effect of gefitinib and gemcitabine on CCC. MATERIALS AND METHODS The effect of gefiti...

UNLABELLED The aim of this study was to determine the role of AKT as a therapeutic target in ovarian clear cell carcinoma (CCC), an aggressive, chemoresistant histologic subtype of ovarian cancer. AKT activation was assessed by immunohistochemistry (IHC) using human tissue microarrays of primary ovarian cancers, composed of both CCC and serous adenocarcinoma (SAC). The growth-inhibitory effect ...