نتایج جستجو برای: fimh
تعداد نتایج: 402 فیلتر نتایج به سال:
Finished genome sequences are presented for four Escherichia coli strains isolated from bloodstream infections at San Francisco General Hospital. These strains provide reference sequences for four major fimH-identified sublineages within the multilocus sequence type (MLST) ST95 group, and provide insights into pathogenicity and differential antimicrobial susceptibility within this group.
TO THE EDITOR—We read with interest the article by Johnson et al, which demonstrates that, in extraintestinal pathogenic Escherichia coli (ExPEC), fluoroquinolone (FQ) resistance is currently associated with the rapid expansion of a single dominant multidrug-resistant (MDR) strain that emerged within sequence type (ST) 131 [1]. Although the strong predominance of the ST131 clone has been well d...
FimH is the type 1 fimbrial tip adhesin and invasin of Escherichia coli. Its ligands are the glycans on specific proteins enriched in membrane microdomains. FimH binding shows high-affinity recognition of paucimannosidic glycans, which are shortened high-mannose glycans such as oligomannose-3 and -5. FimH can recognize equally the (single) high-mannose glycan on uroplakin Ia, on the urinary def...
There is increasing evidence that the catch bond mechanism, where binding becomes stronger under tensile force, is a common property among non-covalent interactions between biological molecules that are exposed to mechanical force in vivo. Here, by using the multi-protein tip complex of the mannose-binding type 1 fimbriae of Escherichia coli, we show how the entire quaternary structure of the a...
زمینه: اشرشیاکلی مهمترین عامل ایجادکننده عفونتهای ادراری در بیماران بستری به ویژه در بخش مراقبتهای ویژه است . کلونیزاسیون این ارگانیسم به واسطه عوامل اتصالی مهم از جمله فیمبریههای نوع 1 ( fimh ) و p ( papc ) به سطوح اپیتلیال مجاری ادراری انجام میشود. هدف: مطالعه به منظور تعیین فراوانی دو ژن کدکننده فیمبریههای نوع 1 و p در اشرشیاکلی مولد عفونت ادراری در بخش مراقبتهای ویژه انجام شد . ...
conclusions the results showed that e. coli isolated from patients with uti had eight virulence factors with high frequencies. moreover, these results alleged a direct connection between virulence factors and antimicrobial resistance in e. coli. results the frequency of virulence factors papc, afa, sfa/foc, fimh, hly, neuc, ibea, and iucc were 53.3%, 51.7%, 53.3%, 56.7%, 23.3%, 31.7%, 20%, and ...
b ackground: the prevalence of urinary tract infection (uti) is really high in the world. escherichia coli is a major agent of uti. one of the strategies for decreasing uti infections is vaccine development. as the attachment is a really important stage in colonization and infection, at- tachment inhibition has an applied strategy. fimh protein is a major factor during bacterial colonization i...
اشریشیا کلای یوروپاتوژنیک، عامل بیماری¬زای اصلی در عفونت¬های مجاری ادراری است. این سویه¬ها فاکتورهای ویرولانس مهمی از جمله آدهسین¬ها، سیدروفورها و توکسین¬ها را حمل می¬کنند که به پیشرفت بیماری عفونت ادراری کمک می¬کند. اولین قدم برای مقابله و مهار این پاتوژن شناسایی فاکتورهای مهم ویرلانس آن است. مطالعات فیلوژنتیک نشان داده است که این باکتری¬ها در چهار گروه a، b1، b2 و d قرار می¬گیرند و نوع گروه ف...
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