We studied the contribution of phasic left atrial (LA) function to left ventricular (LV) filling during exercise. We hypothesized that reduced LV filling time at moderate-intensity exercise limits LA passive emptying and increases LA active emptying. Twenty endurance-trained males (55 ± 6 yr) were studied at rest and during light- (∼100 beats/min) and moderate-intensity (∼130 beats/min) exercis...

Lesion filling has been successfully applied to reduce the effect of hypo-intense T1-w Multiple Sclerosis (MS) lesions on automatic brain tissue segmentation. However, a study of fully automated pipelines incorporating lesion segmentation and lesion filling on tissue volume analysis has not yet been performed. Here, we analyzed the % of error introduced by automating the lesion segmentation and...

OBJECTIVE To assess the early changes in left ventricular diastolic and systolic function due to anthracycline treatment. DESIGN A prospective study of cardiac function by radionuclide angiography in adults before and one month after the end of anthracycline treatment. PATIENTS 60 patients without cardiac disease treated with chemotherapy containing anthracycline. METHODS Cardiac function...

BACKGROUND AND PURPOSE Adjacent fracture formation after percutaneous vertebroplasty has been reported in literature. The purpose of this study was to determine whether intervertebral disk extravasation is related to adjacent fracture formation in low-volume cement-filling vertebroplasty. METHODS A retrospective analysis of 308 patients having vertebroplasty was undertaken. Anteroposterior an...

In 7 conscious dogs, left ventricular diastolic volume (V) was estimated by taking biplane cineradiographs with the left ventricular cavity previously outlined by permanent radiopaque markers. Left ventricular pressure (P) was measured with an implanted miniature transducer. There were two rapid filling periods during early and late diastole; little filling occurred during the middle third of d...

Figure 1: Computing geometric properties of a molecule. As common in biology, atoms are treated as intersecting balls, whose union forms the space-filling diagram. Richards and others proposed to study this union using the Voronoi diagram (or more exactly the power diagram since the balls have different radii). That diagram divides the space into convex cells, one per atom. In the two-dimension...

In 1866 at Carl Ludwig's Physiological Institute at Leipzig, Elias Cyon described the influence of diastolic filling of the isolated perfused frog heart on ejection volume. A study performed at the institute of the effect of filling pressure on contraction amplitude was published in 1869 by Joseph Coats, based on a recording made by Henry P. Bowditch.

Experimental studies have shown that right ventricular filling pressure (that is, intracavitary diastolic pressure) approximates pericardial surface pressure but, in many patients after removal of pericardial effusion, right ventricular filling pressure has been found to markedly exceed pericardial pressure recorded by an open catheter. The aim of this study was to determine whether this appare...

Chemotaxis is one of many mechanisms used by cells and organisms to navigate through the environment, and has been found on scales varying from the microscopic to the macroscopic. Chemotactic movement has also attracted a great deal of computational and modelling attention. Some of the continuum models are unstable in the sense that they can lead to finite time blow-up, or “overcrowding” scenar...