UNLABELLED Systems biology offers considerable promise in uncovering novel pathways by which viruses and other microbial pathogens interact with host signaling and expression networks to mediate disease severity. In this study, we have developed an unbiased modeling approach to identify new pathways and network connections mediating acute lung injury, using severe acute respiratory syndrome cor...

The results of our study may briefly be summarized as follows: 1) The irradiation with microrays (20∼30 watts) similar as 2,000 R and 5,000 R Gamma radiation did not substantially affect the activity of fibrinolysin (SK+SD). 2) By the irradiation method so far mentioned it has been demonstrated that the fibrinolytic activity of anticoagulant of the SK+SD preparation is preserved in all the clot...

The precise mode of therapeutic action of sulfanilamide on streptococcus can be arrived at only by considering the sum total of factors that inhibit or favor the natural growth of the microorganism under the experimental conditions that obtain, whether in vivo or in vitro. Too sweeping conclusions have hitherto been drawn from the study of a single variable factor, such as an unfavorable temper...

Immunological processes have been thought to play a role in rheumatoid arthritis, but no conclusive evidence has yet been obtained. Rheumatoid factor (RA factor) is known to be an antibody-like protein frequently found in the sera of patients with rheumatoid arthritis, but it has not been proved that it has any immediate relationship with the inflammatory processes of the disease, and the speci...

An analysis of the results of the 63 coronary care units in Boston, Massachussets, USA, disclosed no perceptible fall in the hospital mortality from acute myocardial infarction between the years 1973-4 and 19789.1 This disappointing, if not unexpected, reality coupled with the fundamental influence of left ventricular function in determining the prognosis of patients with coronary heart disease...

The prostate gland is about the size and shape of a walnut and weighs in at around one ounce. Women seem to know more about this little gland than men do. About 11% of men don't know that they have this gland in their body. Only 15% of men have ever heard of the term prostatitis. Of the men who do know about prostatitis (inflammation of the prostate), about 16% of them think that this condition...