Fibrin deposition is prominent in the histopathology of a number of inflammatory lung diseases. Plasmin, activated locally in the lung, can degrade not only this fibrin but potentially structural proteins important to normal lung architecture. Because alveolar macrophages are prominent in inflammatory processes of the lung, we examined the plasminogen activator (PA) activity of human alveolar m...

reconstruction methods are an essential prerequisite for functional rehabilitation of the stomatognathic system. plasma rich in growth factors (prgf) offers a new and potentially useful adjunct to bone substitute materials in bone reconstructive surgery. this study was carried out to investigate the influence of prgf and fibrin membrane on regeneration of bony defects with and without deprotein...

Fibrin is formed at sites of injury or inflammation and provides the temporary matrix to support vascular cell responses that are also mediated by cytokines including interleukin-1 (IL-1). We have shown previously that fibroblast growth factor 2 (FGF-2) binds with high affinity to fibrin(ogen). Because IL-1 has a structure similar to FGF-2, we have investigated the possible binding of IL-1 to f...

Adult angiogenesis, associated with pathologic conditions, is often accompanied by the formation of a fibrinous exudate. This temporary matrix consists mainly of fibrin but is intermingled with plasma proteins and collagen fibers. The formation of capillary structures in a fibrinous matrix in vivo was mimicked by an in vitro model, in which human microvascular endothelial cells (hMVECs) seeded ...

The fibrinolytic pathway maintains vascular patency by the proteolytic degradation of fibrin, the end-product of coagulation. Formation of a fibrin mesh during haemostasis is part of the physiological response to vascular injury, whereas thrombosis is a pathological obstruction of blood flow, but the biochemical and cellular participants are believed to be similar. Physiological fibrinolysis is...