One of the limitations of many bridging experiments in neural transplantation is that the CNS tissues cannot be sutured. Fibrin glue is a two-component system derived from whole blood which, when mixed, reproduces the final stage of blood coagulation and solidifies. Many experimental studies of humans and animals show that fibrin glue repair of peripheral nerves is almost equivalent to microsur...

Endoscopic submucosal dissection (ESD) is accepted as a less invasive method of local resection of gastrointestinal tract neoplasia with a negligible risk of lymph node metastasis. ESD facilitates en bloc resection even in patients with larger or ulcerated lesions, thereby preserving the organ and improving the patient’s quality of life compared with surgery. However, it is associated with vari...

After segmental liver resection, a fibrin glue aerosol was used to stop diffuse bleeding from the liver resection site. Immediately after pressurized administration, severe hypotension and bradycardia occurred, requiring cardiopulmonary resuscitation and inotropic support. Transoesophageal echocardiography demonstrated air in both ventricles deriving from the inferior vena cava; contractility o...

A 68-year-old white man with lung carcinoma underwent removal of the lower lobe of the left lung. Four months later, the patient developed a hemothorax requiring exploratory thoracotomy, evacuation of hemothorax, and decortication. Postoperatively a persistent airspace with prolonged air leak developed. Bronchoscopic application of fibrin glue failed to seal the leak. Percutaneous transthoracic...

BACKGROUND Clinical results of ischemic left ventricular free-wall rupture show high mortality rates. METHODS We reviewed studies published after 1993 on PubMed. RESULTS A sutureless technique using fibrin glue sheets or patches with/without fibrin glue might contribute to improved clinical results. However, some technique limitations remain for blowout-type ruptures, and the possibility of...