Objective: To study the clinical efficacy and safety of Medlite C6 q-1064 laser combined with a topical antioxidant serum containing vitamin C, E, ferulic acid(CE Ferulic®, SkinCeuticals Inc) in treatment melasma. Methods: 61 patients melasma were enrolled this single-blind, randomized, split-face controlled study, one side face was treated CE Ferulic, control Q-1064 only. Laser once every 3 we...

Objective: To assess the phenolic acid content of skin, pulp, covering pulp of seed and seed of raw and ripe jackfruit (Artocarpus heterophyllus). Methods: High Performance Liquid Chromatographic (HPLC) analysis was done of various parts of raw and ripe jackfruits. Results: Raw fruit skin was rich in gallic (22.73 μg/g) followed by tannic and ferulic acids. In ripe fruit, the skin had high amou...

Skin is one of the main targets for reactive oxygen species; thus, reactive oxygen species-induced damage and protein and lipid modifications occur, and skin can undergo a wide array of diseases, from photosensitivity to cancer. In this study, human dermal fibroblasts exposed to hydrogen peroxide (0-1000 micromol/L) exhibited a marked increase in both protein carbonyls and 4-hydroxy-2-nonenal, ...

The influence of addition 2,4,6,8, and 10 microM of benzoic and cinnamic acids and selected phenolic acids (salicylic, p-hydroxybenzoic, gentisic, protocatechuic, vanillic, syringic, o-coumaric, p-coumaric, caffeic, ferulic, sinapic) on the activity of pancreatic lipase was examined in vitro. The strongest inhibition activities were observed with caffeic, ferulic and benzoic acid, while sinapic...

Tulipa, Liliaceae, Hydroxycinnamic Acid Conjugates, Ferulic Acid Esters, Sucrose Two ferulic acid conjugates have been isolated from the extract of immature anthers of Tulipa cv. “Apeldoorn” and their structures elucidated using chromatography, electron impact mass spectrometry, and NMR spectroscopy. These two conjugates are 6,3'-diferuloylsucrose and 6,3',4'triferuloylsucrose. High performance...

UNLABELLED BACKGROUND As a typical Chinese herbal medicine, rhizoma Cimicifugae (RC, in Chinese) possesses various pharmacological effects involved in antioxidant activity. However, its antioxidant activity has not been reported so far. The aim of the present study was to systematically evaluate the antioxidant ability of RC in vitro, then discuss the mechanism. METHODS Firstly, five RC ...

In this study, Posidonia oceanica (L.) Delile (Posidoniaceae), which is a widely distributed phanerogam in Aegean and Mediterranean coasts, was investigated for the phenolic compounds that have the potential to be used in pharmaceutical sciences. The leaves, separated as young and mature leaves, were extracted and analyzed by high-performance liquid chromotagraphy (HPLC). The younger leaves wer...

A reaction of 13-hydroperoxide octadecadienoic acid (13-HPODE) with cytochrome c was analysed using ESR, HPLC-ESR and HPLC-ESR-MS by the combined use of the spin-trapping technique. The ESR, HPLC-ESR and HPLC-ESR-MS analyses showed that cytochrome c catalyses formation of pentyl and octanoic acid radicals from 13-HPODE. On the other hand, only the alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone/octa...