Ferritins are ideal nanoparticles as drug delivery systems due to their hollow-sphere structure and the ability target specific receptors on cell surface. Here, we develop characterize a new ferritin derived from chimeric humanized A. fulgidus one, already designed recognize TfR1 receptor. Starting synthetic gene of this protein, replaced two positively charged amino acids with alanine residues...

Abstract We report exceptionally large tunnel magnetoresistance (TMR) for biomolecular junctions based on ferritins immobilized between Ni and EGaIn electrodes. Ferritin stores iron in the form of ferrihydrite nanoparticles (NPs) fulfills following roles: (a) it dictates barrier, (b) magnetically decouples NPs from ferromagnetic (FM) electrode, (c) stabilizes NPs, (d) acts as a spin filter redu...

Microorganisms, Plants, and Animals, offers a comprehensive and timely account of this fascinating topic by 35 distinguished international authorities. In 18 stimulating chapters, this volume highlights first the biological cycling of iron in oceans, followed by accounts of the transport of iron in microorganisms, fungi, and plants, the roles and properties of siderophores, and the regulation o...

Ferritin was isolated from six Morris hepatomas with growth rates ranging from 3 to 12 days doubling time and also from regenerating rat liver. The ferritins from all six tumors differed electrophoretically from normal rat liver ferritin. Five of them migrated identically, and antigenic studies on four confirmed the change in protein structure. In response to iron treatment of the host, more fe...

In contrast to the apparent paucity of Mycobacterium tuberculosis response to reactive oxygen intermediates, this organism has evolved a specific response to nitric oxide challenge. Exposure of M. tuberculosis to NO donors induces the synthesis of a set of polypeptides that have been collectively termed Nox. In this work, the most prominent Nox polypeptide, Nox16, was identified by immunoblotti...

Ferritins store and sequester iron, and regulate iron homeostasis. The cDNA for a stress-responsive phytoferritin, previously identified in the extracellular matrix (ECM) of chickpea (Cicer arietinum), was cloned and designated CaFer1. The CaFer1 transcript was strongly induced in chickpea exposed to dehydration, hypersalinity and ABA treatment. Additionally, it has role in the defense against ...