background: the increase in the rate of infertility in women has prompted the need to search for plants with antifertility potentials. objective: the effect of administration of aqueous extract of cnidoscolous aconitifolius leaves for seven days on reproductive hormones of female wistar rats was investigated. materials and methods: sixty female albino rats were grouped into four (a, b, c and d)...

conclusions the extract contains substances that are effective on the delivery rate, sex ratio, and the number of newborns in the female rats. it may affect through the ionic changes in the rats, by modifying the activity of follicle-stimulating and testosterone hormones, and/or changing the rate of fertilizing ability of sperms containing y chromosome. this phenomenon may also be due to loweri...

The Spontaneously Diabetic Torii (SDT) rat is a spontaneous animal model of non-obese Type 2 diabetes (T2D) resembling those of humans, established in 1997. I investigated the clinical features of the SDT rats. The time of onset of glucosuria was different between male and female SDT rats; glucosuria appeared at approximately 20 weeks of age in male rats and at approximately 45 weeks of age in ...

SUMMARY Obesity is increasing at an alarming rate globally. Several studies have shown that premenopausal women have a reduced risk of CV disease and a reduced myocardial susceptibility to ischaemia/reperfusion injury. The effect of obesity on myocardial tolerance to ischaemia in women has not been established. To determine how obesity affects myocardial susceptibility to ischaemia/reperfusion ...

The hydroxylating activities of liver microsomes for proges terone and testosterone were markedly decreased in male and female rats bearing Walker carcinosarcoma 256. The decreases in the hydroxylating activities were greater in the male rats than in the female rats. The content of cytochrome P-450 in liver microsomes was decreased in the tumor-bearing male and female rats. Moreover, the bindin...

OBJECTIVE To determine the effect of estradiol treatment on serum corticosterone levels in Oophorectomized (OVX) female Sprague Dawley rats exposed to chronic restraint stress. STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Department of Physiology, Army Medical College, Rawalpindi and National Institute of Health, Islamabad, from January to December 2008. METHODOLOGY A tota...

The present study was designed to evaluate the differences in the coronary vasodilator actions of serotonin (5-HT) in isolated heart obtained from naive or castrated male and female rats that were treated with either estrogen or testosterone. Hearts from 12 groups of rats were used: male and female naive animals, castrated, castrated and treated with 17beta-estradiol (0.5 microg kg(-1) day(-1))...

BACKGROUND Trimethylolpropane triacrylate (TMPTA) is used as an ingredient in a wide variety of coatings, resins, photosensitive materials, and superabsorbent baby diapers. We studied the effects of TMPTA on male and female rats and mice to identify potential toxic or cancer-related hazards. METHODS We applied solutions containing TMPTA in acetone on the backs of male and female rats and mice...

Subcutaneous administration of aspartic acid results in a long-lasting but reversible depression of ventilation in male but not in female rats. Aspartic acid acts on N-methyl-D-aspartate receptors. The present study tested the hypothesis that a noncompetitive N-methyl-D-aspartate-receptor antagonist, dextromethorphan (Dex), would depress ventilation in female rats and stimulate it in male rats....

An ethanol oral self administration paradigm showed the existence of gender differences in alcohol preference in rats: whereas males and females initiated alcohol drinking at similar rates, females maintained their preference for ethanol over a longer duration. Neonatal estrogenization of females, which effectively confers a male phenotype on a genetically female brain, resulted in patterns of ...