A 59 years-old Romanian women with a history of HCV-related chronic liver disease, underwent abdominal ultrasound scan. She was totally asymptomatic. The patient was obese (weight: 82 kg, height:165 cm, body mass index (BMI):30,1 kg/m2 ). She referred no pregnancy in her life, menopause at the age of 50 years and no smoke or alcohol assumption. She was affected by arterial hypertension, diabete...

The disposition of tacrolimus and the influence of cyclosporine, troleandomycin, and GF120918 (GG918, or N-[4-[2-(1,2,3,4tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl]-9,10dihydro-5-methoxy-9-oxo-4-acridine carboxamine) on its hepatic disposition were examined in the isolated perfused rat liver. Livers from groups of rats were perfused in a recirculatory manner following a bolus dose ...

Hydrophilic matrices are widely used for extended release drug delivery, with hypromellose (HPMC) being a popular rate-controlling carrier. The FDA has recently issued an alert regarding the potential negative influence of alcohol on extended release dosage forms. The aim of this study was to investigate the hydroalcoholic solution effect on hydration, gel formation and drug release from HPMC m...