Feline herpesvirus-1 and feline calicivirus are common causes of feline upper respiratory tract disease and can cause clinically indistinguishable syndromes. However, they differ in their physical properties, epidemiology, and spectrum of clinical signs; and the differences can affect the diagnosis, prognosis, and management of these infections. The availability and sensitivity of diagnostic te...

Antibody-dependent enhancement of virus infection is a process whereby virus-antibody complexes initiate infection of cells via Fc receptor-mediated endocytosis. We sought to investigate antibody-dependent enhancement of feline infectious peritonitis virus infection of primary feline peritoneal macrophages in vitro. Enhancement of infection was assessed, after indirect immunofluorescent-antibod...

The major internal virion polypeptide from feline and RD-114 type C viruses has been subjected to amino terminal sequence analyses with the Beckman automated sequencer. These proteins, as well as their homologs in rat and mouse viruses, begin with the sequence prolylleucylarginyl (Pro-Leu-Arg). Virus RD-114 differs from conventional feline type C viruses that show about 80 percent relatedness b...

Molar concentration of sodium chloride partially stabilized feline calicivirus against thermal inactivation at 50 C. One strain of feline calicivirus was relatively acid labile compared to another.

A 2-year-old East Friesian sheep imported from Australia exhibited severe anemia after contagious pustular dermatitis in Hokkaido, Japan. Hemoplasma infection was confirmed in blood smears. Both Mycoplasma ovis and 'Candidatus Mycoplasma haemovis' were detected by PCR and sequence analyses. In the epidemiological analysis, dual pathogens were detected in 6 of 12 (50.0%) sheep imported from Aust...

Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we demonstrate that bicyclams are potent inhibitors of feline immunodeficiency virus (FIV) replication when evaluated in Crandell feline kidney (CRFK) cells. With a series of bicyclam derivatives, 50% inhibitory...

A 30 to 40% increase in glucose uptake and lactic acid production was observed during a 48-h period immediately following inoculation of feline fibroblasts and HEp-2 cells with feline leukemia virus. There was no evidence of morphological alterations in either cell type. Immunofluorescent procedures to detect feline leukemia virus group-specific antigen revealed that the feline and HEp-2 cells ...

Only in recent years have specific mutations been elucidated for feline hereditary retinal dystrophies. Molecular genetic characterization of feline diseases has so far been a slow process but with a full genome sequence for the cat recently completed and the development of a feline single nucleotide polymorphism chip, the characterization of feline monogenic disorders will be significantly sim...