While many cell types express receptors for the Fc domain of IgG (Fc gamma R), only primate polymorphonuclear neutrophils (PMN) express an Fc gamma R linked to the membrane via a glycan phosphoinositol (GPI) anchor. Previous studies have demonstrated that this GPI-linked Fc gamma R (Fc gamma RIIIB) cooperates with the transmembrane Fc gamma R (Fc gamma RIIA) to mediate many of the functional ef...

We constructed chimeric receptors to dissect the role of the transmembrane (TM) domain in cell surface expression of and phagocytosis by the chain–dependent Fc receptors Fc RIIIA and Fc RI. Fc R chimeras containing the TM and cytoplasmic (CY) domains of the chain were expressed on the cell surface and mediated an efficient phagocytic signal. In contrast, chimeras containing the Fc RIIIA TM were...

The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped. A common set of IgG1 residues is involved in binding to all Fc gamma Rs, while Fc gamma RII and Fc gamma RIII utilize distinct sites outside this common set. In addition to residues which abrogated binding to the Fc gamma R, several position...

this experiment carried out to evaluate replacing effects of oyster shell (os) with filter cake (fc) of sugar beet industry on performance and quantity and quality of egg in  laying hens .in this trial the filter cake in two physical forms of powder and pellet in  five levels of 0, 25, 50, 75, and 100% replaced for oyster shell. each treatment had 3 replications. the experiment lasted 3 periods...

Abstract. The performance of the Weather Research and Forecasting (WRF) model version 3.8.1 at convection-permitting scale is evaluated by means several sensitivity simulations over southern Peru down to a grid resolution 1 km, whereby main focus on domain with 5 km horizontal resolution. Different configurations microphysics, cumulus, longwave radiation, planetary boundary layer schemes are te...

BACKGROUND Despite poor evidence and high costs, fibrinogen concentrate (FC) represents one of the most frequently used hemostatic agents in exsanguinating trauma. The aim was to assess whether the administration of FC in severely injured patients was associated with improved outcomes. METHODS Patients documented in the Trauma Registry of the German Society for Trauma Surgery (primary admissi...

ige-mediated cell signaling, induced by cross-linking of high affinity receptor for ige (fcεri) in the presence of antigen (ag), is a well known mechanism described for mast cell activation in allergy and hypersensitivity reactions, which induces a spectrum of cellular responses such as secretion and up-regulation of cell surface fcεri. although for several years  ige  binding  to  fcεri  was  ...