Abstract Rapid development of antisense therapies can enable on-demand responses to new viral pathogens and make personalized medicine for genetic diseases practical. Antisense phosphorodiamidate morpholino oligomers (PMOs) are promising candidates fill such a role, but their challenging synthesis limits widespread application. To rapidly prototype potential PMO drug candidates, we report fully...

BACKGROUND Sarcopenia, the progressive decline in skeletal muscle mass and function with age, is a debilitating condition. It leads to inactivity, falls, and loss of independence. Despite this, its cause(s) and the underlying mechanism(s) are still poorly understood. METHODS In this study, small skeletal muscle fibre bundles isolated from the extensor digitorum longus (a fast-twitch muscle) a...

We propose a fast and adjustable sub-optimal path search algorithm for finding minimum error boundaries between overlapping images. The algorithm may serve as an efficient alternative to traditional slow path search algorithms like the dynamical programming. We use the algorithm in combination with novel adaptive blending to stitch image regions. The technique is then exploited in a framework f...

Progress toward a Josephson voltage standard for fast dc measurements and accurate ac waveform synthesis is described. A superconductor-normal-superconductor (SNS) junction process is used to make 5 mA critical current arrays with up to 32 768 junctions. With rf excitation at 11 GHz these arrays generate milliampere constant-voltage steps. A bias control circuit that provides output current amp...