Fenofibrate is a drug of the fibrate class. It is a widely used hypolipidemic drug. The poor aqueous solubility of the drug leads to variable dissolution rates. It is slightly soluble in water. The present investigation was to develop and characterize mouth dissolving tablets of fenofibrate using sublimation technique. Mouth dissolving tablets of Fenofibrate were prepared using different sublim...

Many patient groups, such as the elderly, children, mentally retarded, uncooperative or nauseated, have difficulty in swallowing conventional dosage forms, like tablets. Swallowing conventional tablets will be further hindered by conditions such as unavailability of water, allergic reactions and episodes of coughing1. These problems can be solved by developing rapidly disintegrating and dissolv...

As pharmaceutical scientists are attaining a better understanding of biochemical and physicochemical properties related to the drug action, the drug delivery systems are becoming simple. Fast dissolving tablets (FDTs) have become popular due to better patient compliance and preferred over conventional capsules and tablets. When FDT is put on the tongue, it disintegrates or dissolves rapidly (in...

The present research was aimed to develop the meclizine hydrochloride-polyethylene glycol 20000 solid dispersions to enhance the solubility and dissolution rate. They were prepared using solvent evaporation method and evaluated for solubility studies, drug-carrier compatibility studies and in vitro dissolution studies. From the solubility studies, formulation F4 was selected to prepare the fast...

Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become ...

A spectrophotometric method of assay of mefenamic acid in tablets involving, dissolving the tablet powder in 1,4-dioxane and measuring the absorbance at 353.2 nm. The concentration of mefenamic acid is determined using the previously prepared calibration curve using standard solution of mefenamic acid in dioxane. The method was tested by assay of six different commercial tablets containing mefe...

The objective of this paper was to review the information about mouth dissolvi improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have acquired an important position in the market b and contributing to extension of patent life. MDDDS have the unique property of rapi...

Purpose of current research work was to develop mouth dissolving tablets of Loperamide HCl with enhanced solubility and palatable taste. Mouth dissolving tablets of Loperamide HCl were prepared by the directcompression method. Skimmed milk was used as natural polymer. Improvement in dissolution rate of drug was observed in solid dispersion as compared to pure drug. All the batches of the tablet...