Thyroid cancer is the sixth most common cancer in women, and the majority of patients with thyroid cancer has sporadic disease. However, about 25% of patients with medullary thyroid cancer and 5% with papillary thyroid cancer have familial tumors. Currently, there are numerous controversies regarding the mode of inheritance, tumor behavior, extent of surgical resection for optimal results, coex...

PURPOSE Most familial cancer susceptibility genes are tumor suppressor genes that are biallelically inactivated in familial neoplasms through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in pancreatic neoplasms, particularly those that occur in familial and precursor neoplasms, may help localize the genes responsible for pancreatic cancer susceptibility. ...

In this study, it was aimed to find the percentage of the non-familial and familial cases and comparison of their characteristic susing 2004 Canadian criteria in our cancer patients. The data from the files of 200 patients with histopathologically proven gastric cancer registered in our Medical Oncology Clinic were evaluated between January 2001 and December 2005. In our study, the ratio of fam...

BACKGROUND Pancreatic cancer is a deadly disease. Discovery of the mutated genes that cause the inherited form(s) of the disease may shed light on the mechanism(s) of oncogenesis. Previously we isolated a susceptibility locus for familial pancreatic cancer to chromosome location 4q32-34. In this study, our goal was to discover the identity of the familial pancreatic cancer gene on 4q32 and dete...

Abbreviations used in this paper: AFAP, attenuated familial adenomatous polyposis; AGA, American Gastroenterological Association; AUC, area under the curve; CI, confidence interval; CRC, colorectal cancer; FAP, familial adenomatous polyposis; HNPCC, hereditary nonpolyposis colorectal cancer; IHC, immunohistochemistry; MAP, MUTYH-associated polyposis; MMR, mismatch repair; MSI, microsatellite in...

Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of 74 studies reporting data on familial aggregation of prostate cancer in unselected populations retrieved by a Pubmed search and browsing references, 33 inde...

BACKGROUND & AIMS An attenuated form of familial adenomatous polyposis has been described, but the phenotype remains poorly understood. METHODS We performed genetic testing on 810 individuals from 2 attenuated familial adenomatous polyposis kindreds harboring an identical germline adenomatous polyposis coli gene mutation. Colonoscopy was performed on mutation-positive persons. RESULTS The d...

PURPOSE Familial pancreatic cancer describes families with at least two first-degree relatives with pancreatic cancer that do not fulfil the criteria of other inherited tumor syndromes with increased risks of pancreatic cancer. Although much has been learned regarding the aggregation of pancreatic cancer in some families, the genetic basis for this familial aggregation is poorly understood. Thi...

BACKGROUND Familial component is estimated to account for about 10% of ovarian cancer. However, the mode of inheritance of ovarian cancer remains poorly understood. The goal of this study was to investigate the inheritance model that best fits the observed transmission pattern of ovarian cancer among 7669 members of 1919 pedigrees ascertained through probands from the Gilda Radner Familial Ovar...

A familial relationship between intestinal polyposis and the predisposition of polyposis to colonic cancer has been accepted since the publication in 1952/1953 of Dukes's paper. He collected information on every patient presenting at St Mark's Hospital with polyposis coli and investigated the family background in each case. He was able to study 41 families, trace 156 cases of polyposis, and 114...