BACKGROUND Evaluating the potential risk of metabolic drug-drug interactions (DDIs) is clinically important. OBJECTIVE To develop a physiologically based pharmacokinetic (PBPK) model for sarpogrelate hydrochloride and its active metabolite, (R,S)-1-{2-[2-(3-methoxyphenyl)ethyl]-phenoxy}-3-(dimethylamino)-2-propanol (M-1), in order to predict DDIs between sarpogrelate and the clinically releva...

Guanidine hydrochloride has been widely used in the initial recovery steps of active protein from the inclusion bodies in aqueous two-phase system (ATPS). The knowledge of the guanidine hydrochloride effects on the liquid-liquid equilibrium (LLE) phase diagram behavior is still inadequate and no comprehensive theory exists for the prediction of the experimental trends. Therefore the effect the ...

This study aimed to explore the role and mechanism(s) of flunarizine hydrochloride in the intracerebral hemorrhage (ICH) rats. The 32 adult male Sprague Dawley (SD) rats were randomly assigned into four groups: control group, sham group, ICH group, and FLU + ICH group. The effects of flunarizine hydrochloride were assessed on the basis of hematoma volume, blood-brain barrier (BBB) integrity, an...

Aim:The purpose of this in vitro study wasto evaluate whether the toxic effects are reduced by using combination 0.5% Benzydamine hydrochloride along with 0.2% Chlorhexidine gluconate and to compare it 0.2 % alone. Materials Methods: Two groups a total 160 cultured cell samples consisting 80 each Control group (0.2% Gluconate alone)and Experimental (Combination 0.15% Hydrochloride). Again subdi...

order terbinafine online terbinafine online purchase terbinafine 250mg treatment terbinafine hcl 250 mg tablet apo terbinafine hydrochloride 250 mg tablet terbinafine no prescription terbinafine tablets prices apo terbinafine 250 mg terbinafine hydrochloride antifungal cream 1 terbinafine prescription online terbinafine cream rxlist terbinafine hcl 250mg tablet prescription strength terbinafine...

A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of Nebivolol hydrochloride and Cilnidipine in tablet dosage form. A Spheri-5-RP-18 column having 250×4.6 mm i.d., with mobile phase composed of Methanol: 20 mM Ammonium acetate (85:15, v/v; pH 4.0 adjusted with Formic acid. The rete...

clonidine hydrochloride is an antihypertensive agent used for migraine prophylaxis, attention deficit hyperactivity disorder, menopausal flushing and tourette syndrome. the quantity of the active substance in pharmaceutical preparations must be within specific limits, in agreement with the respective label claim. therefore, the aim of this study was to establish the conditions for two spectroph...

IMPORTANCE Short-term studies suggest antidepressants are associated with modest weight gain but little is known about longer-term effects and differences between individual medications in general clinical populations. OBJECTIVE To estimate weight gain associated with specific antidepressants over the 12 months following initial prescription in a large and diverse clinical population. DESIG...

Analgesic effects were conducted with 2% lignocaine hydrochloride (LH), 2% lignocaine hydrochloride with adrenaline (LHA) and 0.5% bupivacaine hydrochloride (BH) in calves of both sexes. Analgesic drugs were injected into caudal epidural space in 30 apparently healthy calves of below one year of age. A total of 30 analgesic trials were done, where heart rate, respiration rate and rectal tempera...