Plasma factor XIII is composed of two subunits, a and b, whereas platelet and other intracellular zymogens have only a-subunits. The catalytic subunit, a. is the same in all forms. In order to characterize the interactions of awith b-chains in the plasma zymogen and a-chains with other molecules and to correlate factor XIII activity with aprotein. a specific, sensitive radioimmunoassay was deve...

1. Arad A, Proulle V, Furie RA, Furie BC, Furie B. beta2 glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood. 2011; 117(12):3453-3459. 2. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibito...

Coagulation factor XIII (FXIII) is converted by thrombin and Ca(2+) into an active transglutaminase (FXIIIa) in the final phase of coagulation cascade. Its main function is the mechanical stabilization of fibrin clot and its protection from fibrinolysis by cross-linking of fibrin chains and α(2)-plasmin inhibitor to fibrin. In non-substituted patients FXIII deficiency is a severe hemorrhagic di...

Pelvic examination showed that it was normal and adequate for vaginal delivery. Her haemoglobin at the time of booking was 12 g/dl, group 0, rhesus positive. Haemoglobin electrophoretic pattern was A+C. Serological test was negative. Urine analysis showed no abnormality. The pregnancy progressed normally and she went into labour spontaneously at term. On 18 February 1976, after being in labour ...

Pelvic examination showed that it was normal and adequate for vaginal delivery. Her haemoglobin at the time of booking was 12 g/dl, group 0, rhesus positive. Haemoglobin electrophoretic pattern was A+C. Serological test was negative. Urine analysis showed no abnormality. The pregnancy progressed normally and she went into labour spontaneously at term. On 18 February 1976, after being in labour ...

The inhibitory effect of coagulation factor XIII (FXIII) on fibrinolysis has been studied for at least 50 years. Our insight into the underlying mechanisms has improved considerably, aided in particular by the discovery that activated FXIII cross-links α2-antiplasmin (α2AP) to fibrin. In this review, the most important effects of different cross-linking reactions on fibrinolysis are summarized....

Pools of factor XIII (FXIII) exist in the plasma and within the cytoplasm of hematopoietic cells, including platelets. The functions of the cellular form, FXIII-A, have been assumed to be intracellular in nature, as the protein lacks a signal sequence for its release. Mounting evidence now suggests that platelet FXIII-A modulates hemostasis by several different mechanisms. In this condensed rev...

Frequency-shifted feedback (FSF) lasers are potential candidates for long distance telemetry due to the appearance of beatings in the noise spectrum at the output of a homodyne interferometer: the frequencies of these beatings vary linearly with the path delay. In this Letter we demonstrate that these beatings also occur in the heterodyne mixing of two identical, but distinct, FSF lasers. This ...

INTRODUCTION: Callus distraction is a well-accepted method for treating large bone defects. Unfortunately, the time for the maturation of a newly formed regenerate is long and can lead to complications. A method which would allow the acceleration of the maturation process would shorten the treatment time, reduce the costs and would be a great benefit for the patients. Plasma factor XIII has dem...