A β-sheet-binding scaffold was equipped with long-range chemical groups for tertiary contacts toward specific regions of the Alzheimer's Aβ fibril. The new constructs contain a trimeric aminopyrazole carboxylic acid, elongated with a C-terminal binding site, whose influence on the aggregation behavior of the Aβ(42) peptide was studied. MD simulations after trimer docking to the anchor point (F1...

abstract:we define as south asian countries those countries that start with iran and end with bangladesh in asia. wethen use export statistics in terms of revealed comparative advantage (rca) for 14 industrial sectors tomeasure distances of export capabilities for these countries in relation to the “western” developed and eastasian countries. statistical methods such as multidimensional sca...

The gut microbiome interacts with the host in the metabolic response to diet, and early microbial aberrancies may be linked to the development of obesity and metabolic disorders later in life. Probiotics have been proposed to affect metabolic programming and blood lipid levels, although studies are lacking in infants. Here, we report on the lipid profile and global metabolic response following ...

Li L, Black R, Ma Z, Yang Q, Wang A, Lin F. Use of mouse hematopoietic stem and progenitor cells to treat acute kidney injury. Am J Physiol Renal Physiol 302: F9–F19, 2012. First published September 21, 2011; doi:10.1152/ajprenal.00377.2011.—New and effective treatment for acute kidney injury remains a challenge. Here, we induced mouse hematopoietic stem and progenitor cells (HSPC) to different...

Glycolytic potential (GP) in skeletal muscle is economically important in the pig industry because of its effect on pork processing yield. We have previously mapped a major quantitative trait loci (QTL) for GP on chromosome 3 in a White Duroc × Erhualian F2 intercross. We herein performed a systems genetic analysis to identify the causal variant underlying the phenotype QTL (pQTL). We first con...

We have developed a strategy for the design of miniature proteins that bind DNA[1-3] or protein surfaces[4-7] with high affinity and selectivity. This strategy, which is often called protein grafting,[8-11] involves dissecting a functional recognition epitope from its native α-helical or polyproline type II (PPII) helical context and presenting it on a small but structured protein scaffold (Fig...

AIMS To describe patterns of ICD-10 classification of illicit drug-induced deaths (DID) in the General Mortality Register (GMR), to assess the applicability of the European criterion (which excludes the X44 code) to extract these deaths from the GMR, and to estimate drug-induced mortality in Spain by applying a correction index for underestimation. METHODS DID between 1999 and 2007 were extra...

BACKGROUND Probiotic bacteria are suggested to play a role in the maintenance of oral health. Such health promoting bacteria are added to different commercial probiotic products. The aim of the study was to investigate the ability of a selection of lactobacilli strains, used in commercially available probiotic products, to inhibit growth of oral mutans streptococci and C. albicans in vitro. M...