F1-V is a recombinant plague antigen comprising the capsular (F1) and virulence-associated (V) proteins. Given intramuscularly with Alhydrogel, it protects mice against challenge, but is less effective in non-human primates against high-dose aerosolized Yersinia pestis challenge, perhaps because it fails to induce respiratory immunity. Intranasal immunization of mice with F1-V formulated with a...

Juvenile fish trade monitoring is an important task on Brazilian fish farms. However, the identification of juvenile fish through morphological analysis is not feasible, particularly between interspecific hybrids and pure species individuals, making the monitoring of these individuals difficult. Hybrids can be erroneously identified as pure species in breeding facilities, which might reduce pro...

Let F1, . . . ,Fr ⊂ ([n] k ) be r-cross t-intersecting, that is, |F1 ∩ ·· · ∩Fr| ≥ t holds for all F1 ∈ F1, . . . ,Fr ∈ Fr. We prove that for every p,μ ∈ (0,1) there exists r0 such that for all r > r0, all t with 1 ≤ t < (1/p− μ)r−1/(1− p)−1, there exist n0 and ε so that if n > n0 and |k/n− p|< ε , then |F1| · · · |Fr| ≤ (n−t k−t )r .

F1-ATPase (F1) is a multisubunit water-soluble domain of FoF1- ATP synthase and is a rotary enzyme by itself. Earlier genetic studies using yeast suggested that two factors, Atp11p and Atp12p, contribute to F1 assembly. Here, we show that their mammalian counterparts, AF1 and AF2, are essential and sufficient for efficient production of recombinant bovine mitochondrial F1 in Escherichia coli ce...

This paper investigates the properties of the widely-utilized F1 metric as used to evaluate the performance of multi-label classifiers. We show that given an uninformative binary classifier, F1-optimal thresholding is to predict all instances positive. More surprisingly, we prove a relationship between the optimal threshold and the best achievable F1 score over all thresholds. We demonstrate th...

The application of our glueball-qq̄ filter to the centrally produced KK̄π system shows that the f1(1285) and f1(1420) have the same behaviour; namely consistent with the f1(1420) being the partner to the f1(1285) in the P1 nonet of axial mesons. We determine a flavour singlet-octet mixing angle of ∼ 50 for this nonet and highlight that the existence of the supposed f1(1510) needs confirmation. e-...

F1-ATPase (F1) is a reversible ATP-driven rotary motor protein. When its rotary shaft is reversely rotated, F1 produces ATP against the chemical potential of ATP hydrolysis, suggesting that F1 modulates the rate constants and equilibriums of catalytic reaction steps depending on the rotary angle of the shaft. Although the chemomechanical coupling scheme of F1 has been determined, it is unclear ...

Plague is one of the most dangerous infections in humans caused by Yersinia pestis, a Gram-negative bacterium. Despite of an overwhelming research success, no ideal vaccine against plague is available yet. It is well established that F1/LcrV based vaccine requires a strong cellular immune response for complete protection against plague. In our earlier study, we demonstrated that HSP70(II) of My...