purpose : studies show that phenytoin is effective in improvement of different chronic ulcers such as venous stasis ulcers, and diabetic ulcers. the exact mechanism is yet not clear investigators thought that phenytoin might help to heal intractable corneal ulcers by reducing inflammation, differentiating limbal fibroblasts, and promoting the invasion of the cornea with new blood vessels as sho...

PURPOSE To evaluate the safety of bromfenac sodium eye drops from the standpoint of corneal sensitivity and tear secretion in healthy controls following instillation for 1 month. METHODS A prospective single-blind parallel clinical study was conducted in 20 eyes of ten healthy volunteers with no history of ocular or systemic allergic disease, dry eye, contact lens wear, or ocular surgery. Par...

purpose : to describe a case of bilateral squamous cell carcinoma in right nasal and left temporal conjunctiva, simulating bilateral pterygium case report : a reddish fibrovascular pterygium-like lesion was observed in the nasal side of bulbar conjunctiva on the right eye and temporal conjunctiva of the left eye. medical examination not revealed any coexistent malignancy elsewhere excisional bi...

AIM To determine the force needed to extract a drop from a range of current prostaglandin monotherapy eye droppers and how this related to the comfortable and maximum pressure subjects could exert. METHODS The comfortable and maximum pressure subjects could apply to an eye dropper constructed around a set of cantilevered pressure sensors and mounted above their eye was assessed in 102 subject...

Purpose: To evaluate safety and tolerability on the ocular surface of an anti-septic formulation containing 0.6% povidone–iodine (0.6% PVI) for a 4 week period. Methods: An observational, prospecti...

PURPOSE To evaluate the effect of tetracaine on intraocular pressure (IOP) in normal and hypertensive rabbit eyes. METHODS The study was conducted on 12 healthy rabbits as controls and 6 healthy rabbits in which an experimental model of ocular hypertension (OHT) was induced by administration of 70 mL/kg of tap water through an orogastric tube. One drop of tetracaine was instilled in the left ...

PURPOSE To assess the effect of patient education on videotaped topical instillation of artificial tear drops on subsequent topical instillation. MATERIALS AND METHODS Forty-five patients, who had been using glaucoma drops for at least 6 months and with a best-corrected visual acuity of 20/100 or better, were studied. The patients were asked to instill an artificial tear drop using their accu...

PURPOSE To study the effect of patient education and the TravAlert(®) -Eyot(®) drop guider on intraocular pressure (IOP) and adherence in patients with primary open angle glaucoma (POAG) or ocular hypertension (OHT) monitored with the TravAlert(®) dosing aid. METHODS Multicentre, randomized, controlled clinical trial among 18 Dutch hospitals. Patients were randomized to one of the four study ...

Aims: To assess the ocular bioavailability of fluorescein from a novel water free, freeze dried ophthalmic drug delivery system compared to conventional preservativefree fluorescein eye drops. Methods: Sodium fluorescein 0.17% was dissolved in an aqueous solution of hydroxypropylmethyl cellulose 1.0% (HPMC), deposited on sterilised flexible hydrophobic poly(tetrafluoroethylene) (PTFE) carrier s...