نتایج جستجو برای: extranodal nk
تعداد نتایج: 23657 فیلتر نتایج به سال:
Extranodal NK/T cell lymphoma (ENKTL), nasal type is a rare, aggressive disease affecting the midfacial and nasopalatal region in the head. The pathogenesis of the disease is unknown, but the disease has been linked to Epstein Barr virus (EBV) infection. Early diagnosis of the disease is the best way to increase the prognosis and quality of life in the patients. However, it is still a challenge...
The new World Health Organization / European Organization for Research and Treatment of Cancer (WHO-EORTC) consensus classification for cutaneous lympho-mas recognizes two main groups of CD56 + lymphomas: extranodal natural killer (NK)/T-cell lymphoma nasal type, and CD56+ haematodermic neoplasm (formerly known as blastic NK cell lymphoma (1). NK/T-cell lymphoma nasal type is the most common ly...
We report a case of a 38-year-old male with extranodal NK/T-cell lymphoma, nasal type, showing unusual clinical and pathological features. The patient was admitted for soft tissue swelling and tenderness in both legs. The patient had been treated intermittently 8 months prior for repeated muco-cutaneous ulcers. A muscle biopsy showed medium-sized atypical lymphoid cells with bizarre nuclei and ...
BACKGROUND Mature T-cell and natural killer (NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas, and extranodal NK/T-cell lymphoma, nasal type (ENKTL) is an aggressive subtype with sporadic CD30 expression. However, the significance of CD30 expression in ENKTL is controversial. We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas accord...
BACKGROUND The prognosis for patients with most forms of T-cell lymphoma is poor. Allogeneic hematopoietic stem-cell transplantation (HSCT) may improve the outcome. PATIENTS AND METHODS This study examines the outcome of 52 patients who underwent ablative or nonablative allogeneic HSCT for peripheral T-cell lymphoma (PTCL) or advanced mycosis fungoides/Sezary syndrome over a 12-year period at...
Mature natural killer (NK) cell neoplasms are classified by the World Health Organization into NK/T cell lymphoma, nasal type (NKTCL), aggressive NK-cell leukemia (ANKCL) and chronic lymphoproliferative disorders of NK-cells, the latter being considered provisionally. NKTCL and ANKCL are rare diseases, with higher prevalence in Asia, Central and South America. Most NKTCL present extranodal, as ...
6q21 genetic deletion has been frequently detected in extranodal NK/T cell lymphoma, nasal type (EN-NK/T-NT), and PRDM1 is considered as candidate gene. However, direct detection of PRDM1 deletion has not been well documented. We investigated genetic alterations of 6q21 and PRDM1 in 43 cases of EN-NK/T-NT and cell lines by FISH. PRDM1 expression was evaluated by immunohistochemistry and Western...
Aggressive natural killer cell leukemia (ANKL) is a fatal hematological neoplasm characterized by a fulminating clinical course and extremely high mortality. Current diagnosis of this disease is not effective during the early stages and it is easily misdiagnosed as other NK cell disorders. We retrospectively analyzed the clinical characteristics and flow cytometric immunophenotype of 47 patient...
Recently, as we experienced a case of extranodal NHL originating from the masseter musclecompletely cured by chemotherapy with radiotherapy, present clinical, US, CT, andMR imaging findings in additional one biopsy-proved (NK/T celllymphoma) involving predominantly muscle also review thoroughly our collectedcases primary non-Hodgkin’s lymphoma muscles mastication and facialexpression. On basis ...
Extranodal natural killer/T-cell lymphoma (ENKTL), nasal type, is a distinct entity of non-Hodgkin lymphoma with interesting unique biologic and clinicopathologic features. The tumor is characterized by ethnic preponderance, a consistent association with Epstein-Barr virus (EBV) infection, peculiar histopathologic findings, and a predilection to affect primarily the upper aerodigestive tract, i...
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