Angiogenesis is the process of neovascularization from parent blood vessels, which is a prerequisite for many physiological and pathological conditions and is regulated by a balance between endogenous angioinhibitors and angioactivators or angiogenic factors. Imbalance between angioinhibitors and angioactivators is associated with neovascularization capacity during progression of tumor developm...

OBJECTIVE The right ventricle in hypoplastic left heart syndrome (HLHS) works at systemic pressure and large volume loading before and after first stage palliation. There is a paucity of information regarding the intrinsic characteristics of the right ventricle in HLHS. We studied extra-cellular matrix composition, myocyte homeostasis and gene expression in right ventricular biopsies obtained f...

Dupuytren's disease, (DD), is a fibroproliferative condition of the palmar fascia in the hand, typically resulting in permanent contracture of one or more fingers. This fibromatosis is similar to scarring and other fibroses in displaying excess collagen secretion and contractile myofibroblast differentiation. In this report we expand on previous data demonstrating that POSTN mRNA, which encodes...

UNLABELLED The vocal fold structure is composed of tissues with many cells surrounded by the extra-cellular matrix. One of the most important components of the extra-cellular matrix is Hyaluronic Acid (HA). The aim of the study was to evaluate the inflammatory response of rabbit vocal folds after a local injection of Restylane HA. METHODS Twelve adult male rabbits randomly received a 0.1 ml i...

objective: the gingival crevicular fluid (gcf) is an inflammatory exudate found in the gingival sulcus. the forces exerted during orthodontic treatment cause distortion of the periodontal ligament (pdl) extra-cellular matrix, resulting in some biological features that can lead to modification of both gcf volume and its components. the present study investigated the effect of orthodontic tooth m...

nicotine is an alkaloid by high level of addictive property that can quickly assimilate from smoker’s lung. it passes from the placenta and gathers in the developing fetus. our previous study showed that collagen type iv plays a critical role in basement membrane of different embryonic organs. in this study the effect of maternal nicotine was evaluated by collagen iv changes in lung of mice off...

Abstract Extracellular vesicles (EVs) are bilayer-membrane-bound isolated from biofluids and tissues. Recently, these organelles have been recognized as a novel mode for inter intra-cellular communication. The three critical subtypes of EVs include exosomes, microvesicles, apoptotic bodies. They can be discriminated according to their size, cargo, biogenesis, release pathways, functions. These ...

Ameloblastin (AMBN), an important component of the self-assembled enamel extra cellular matrix, contains several in silico predicted phosphorylation sites. However, to what extent these sites actually are phosphorylated and the possible effects of such post-translational modifications are still largely unknown. Here we report on in vitro experiments aimed at investigating what sites in AMBN are...