Macrophages from mice bearing large D1-DMBA-3 mammary tumors have a decreased capacity to kill tumor targets. This effect is due to an impaired ability to produce nitric oxide (NO) in response to lipopolysaccharide (LPS) stimulation. Here we report that the DA-3 tumor cell line, derived from the in vivo adenocarcinoma D1-DMBA-3, produces a factor that inhibits both NO production/release and cyt...

REFERENCES LEDINGHAM, I. McA., MCARDLE, C. S. & PARRATT, J. R. (1972). Comparison of a coronary vasodilator drug (carbochromen) and a cardiac stimulant (oxyfedrine) on blood flow and oxygen extraction in experimental myocardial infarcts. Br. J. Pharmac., 44, 323-324P. MARSHALL, R. J. & PARRATT, J. R. (1973). The effect of noradrenaline on blood flow and oxygen consumption in normal and ischaemi...

Abstract There are no mirror-image pairs of languages. This restriction on the otherwise vast set possible languages must be accounted for, and puts boundary conditions any theory human language faculty. implications for externalization in longer run evolution Antisymmetric linear/temporal order is part core syntax. Temporal partly (though not fully) integrated into syntax via Merge itself. Whe...

PurposeChronic lung allograft dysfunction (CLAD) is the primary cause of long-term mortality after transplantation. Aspiration bile acids has been associated with CLAD and lipidomic dysregulation. This study evaluates role large airway bronchial wash (LABW) lipidomics diagnosis CLAD.MethodsLABW (n=611) samples were obtained from 305 transplant recipients at different timepoints. Concentrations ...

Background and Objectives: Our aim was to evaluate the association between dietary serine intakes and hypertension incident. Materials and Methods: We used the data of 4287 subjects aged 20-70 years, who participated in the fourth phase of Tehran Lipid and Glucose Study (2008-2011)  and were followed up to the fifth  phase (2011-2014). At baseline, the participants were free of hyp...

Metal halide perovskites have shown great potential for lighting. However, their low stability under irradiation/thermal stress and/or ambient storage conditions are critical light-emitting diodes (LEDs). Among the stabilization strategies, ligand surface modification is effective toward stable perovskites, but dynamic adsorption/desorption process on a limiting factor. Herein, new family of bi...

The increasing emergence of drug-resistant fungal pathogens, together with the limited number available antifungal drugs, presents serious clinical challenges to treating systemic, life-threatening infections. Repurposing existing drugs augment activity well-tolerated antifungals is a promising strategy potential be implemented rapidly. Here, we explored mechanism by which colistin, positively ...

A highly active phospholipase D that is specific for cardiolipin was detected in the gram-negative bacterium Haemophilus parainfluenzae. Previously reported phospholipase D preparations have come exclusively from higher plants. The bacterial enzyme hydrolyzed cardiolipin to phosphatidyl glycerol and phosphatidic acid. During the incubation, phosphatidic acid disappeared. Phosphatidyl ethanolami...