Direct current electrotherapy was demonstrated to be an effective and relatively inexpensive local treatment of murine solid subcutaneous tumours. The insufficient knowledge of the mechanisms involved hinders its more extensive use in clinical oncology. Attempts were made to establish the correlation between the effectiveness of electrotherapy and deposition of the electrode material in the tum...

PURPOSE To determine the risk factors for recurrence of giant cell tumours (GCTs) of bone. METHODS Medical records of 29 men and 29 women (mean age, 34 years) treated for primary (n=53) or recurrent (n=5) GCTs of bone and followed up for a mean of 40.2 months were reviewed. The tumours were located in the distal femur (n=18), proximal tibia (n=10), proximal femur (n=8), distal radius (n=7), p...

Reproductive tract tumours, specifically leiomyoma, are commonly found in female rhinoceroses. Similar to humans, tumour growth in rhinoceroses is thought to be sex hormone dependent. Tumours can form and expand from the onset of ovarian activity at puberty until the cessation of sex-steroid influences at senescence. Extensive tumour growth results in infertility. The aim of this study was to d...

Background αVβ3, αVβ5 and α5β1 integrins are known to be involved in carcinogenesis and are overexpressed in many types of tumours compared to healthy tissues; thereby they have been selected as promising therapeutic targets. Positron emission tomography (PET) is providing a unique non-invasive screening assay to discriminate which patient is more prone to benefit from antiangiogenic therapies,...

objective(s): gallium‐68 (ga‐68) is an ideal research and hospital‐based pet radioisotope. currently, the main form of ga‐68 radiopharmaceutical that is being synthesised in‐house is ga‐68 conjugated with dota based derivatives. the development of automated synthesis systems has increased the reliability, reproducibility and safety of radiopharmaceutical productions. here we report on our three...

Introduction: Myofibroblastic sarcoma is designated as a low-grade malignancy, commonly affecting the deep soft tissue of head and neck. Despite being classified low-grade, myofibroblastic with high-grade features have been reported. Observations: Two such cases oral cavity, which were diagnosed different entities upon biopsy, observed. Case 1 presented multiple, well-circumscribed swellings to...

Solid tumours account for 90% of all cancers. Gene therapy represents a potential new modality for their treatment. Up to now, several approaches have been developed, but the most efficient ones are the viral vector based gene therapy systems. However, viral vectors suffer from several deficiencies: firstly most vectors currently in use require intratumoural injection to elicit an effect. This ...

background: definite data regarding the incidence and distribution of renal tumours in eastern india is not known. for better management, as it is essential to identify patients with poor prognosis, prognostic factors like stage, nuclear grade and their relationship to molecular markers are also unclear in this region. the purpose of our study was to assess the spectrum of adult renal tumours w...

A tumoral mass at the clivus is uncommon and its differential diagnosis presents a challenge, since many different tumours may result in a similar radiological image. A chordoma is the most common of these tumours and represents 40% of all cases. Less common, in decreasing order of frequency, are meningiomas, astrocytoma, germinal cell tumours, lymphoma, metastases and, finally, pituitary adeno...

Forty nine patients with rectosigmoid carcinoma considered unsuitable for surgery underwent endoscopic Nd:YAG laser treatment for paliiation of symptoms and tumour eradication, if feasible. Altogether 25 (51%) of the lesions had distal margins less than 7 cm from the anus and 36 (73%) extended above the peritoneal reflection. In seven patients with tumours less than 3 cm in diameter, symptomati...