Export of mRNA from the nucleus is a central process in eukaryotic gene expression that has been implicated in several human diseases. Much of our understanding of how an mRNA is transported to the cytoplasm is derived from studies using yeast and fly models. We present here different mechanisms by which aberrant nuclear retention of mRNA can cause human disease. Emerging evidence that implicat...

In eukaryotic cells, the nuclear membrane creates a barrier between the nucleus and the cytoplasm. Whereas RNA synthesis occurs in the nucleus, they mostly function in the cytoplasm; thus export of RNA molecules from the nucleus to the cytoplasm is indispensable for normal function of the cells. The molecular mechanisms involved in each kind of cellular RNA export is gradually understood. The f...

To survive in the business, especially the online, world, an enterprise requires an effective security infrastructure. However, enterprises should bear in mind that there is often also a legal obligation to keep certain data or information secure, emanating from legislation such as intellectual property, data protection or trade secret legislation or from contract. A number of technological mea...

In power plant applications, detailed transient analysis of the evaporator results in very large fluid systems, i.e. the model consists of many equations. This is because the evaporator has many tubes and the spatial discretization has to be quite fine in order to appropriately model transient evaporation processes. In such cases, due to performance and workflow reasons, we use a specialized in...

a diversification of the country’s export structure through the concerted development of its export-oriented manufacturing capacity could offer a viable alternative, as also stipulated in the country’s second socioeconomic and cultural development plan, by increasing the resilience of its economy against external shocks, supporting employment creation and technological innovation, and adding do...

raisin is the second major export item in iranian agricultural section after pistachio. in this study, effects of exchange rate fluctuations were investigated on quantity and price of exported raisin. therefore, data of 1970 to 2008 were reviewed by time series analysis and estimated by auto-regressive distributed lag model (ardl). results show the absence of a long-term relationship between ex...

Several factors contribute to nuclear mRNA export in Saccharomyces cerevisiae, including Mex67p, Mtr2p, Gle1p, Nup159p, Dbp5p, and Rip1p. Strains carrying mutations in these factors show rapid and dramatic nuclear accumulation of poly(A)(+) RNA. We have characterized two heat shock mRNAs, SSA4 and HSP104, in these mutant backgrounds; each transcript concentrates in a single intranuclear focus. ...

Small scale industries (SSI) have a significant role in the Indian economy in view of its contribution to production, employment, and export. However, since 1991 small scale industries in India find themselves in an intensely competitive environment due to globalization, domestic economic liberalization, and dilution of sector specific protective measures. The formation of World Trade Organizat...

1930 (adjusting the 1930 prices for general inflation). Use of e-mail and access to the Internet, unheard of in 1930, reduce costs even further. The most important reason that trade has expanded so rapidly, however, is that government restrictions on trade between countries have come down. Western European countries are integrating into a single market. Canada, Mexico, and the United States hav...

BACKGROUND Tobacco companies target young adults through marketing strategies that use bars and nightclubs to promote smoking. As restrictions increasingly limit promotions, music marketing has become an important vehicle for tobacco companies to shape brand image, generate brand recognition and promote tobacco. METHODS Analysis of previously secret tobacco industry documents from British Ame...