INTRODUCTION The effect of expiratory endotracheal tube (ETT) resistance on dynamic lung inflation is unknown. We hypothesized that ETT resistance causes dynamic lung hyperinflation by impeding lung emptying. We further hypothesized that compensation for expiratory ETT resistance by automatic tube compensation (ATC) attenuates dynamic lung hyperinflation. METHODS A ventilator equipped with th...

Improvement in the results of tests of ventilatory function in response to a bronchodilator drug, given by inhalation or by injection, is now widely used to indicate the presence of reversible " bronchospasm" (Rossier, 1949; Gilson and Hugh-Jones, 1955; Kennedy and Thursby-Pelham, 1956). Frequent repetition of some of these tests in a small series of patients has revealed an interesting relatio...

Electronic spirometers offer the prospect of paperless home monitoring, but data quality is not automatically better than from conventional monitoring. The aim of this study was to determine the extent to which the quality and processing of self-recorded spirometric data from patients with asthma complied with international guidelines for spirometry. Data were from 33 subjects with poorly contr...

Our main aim was to determine an appropriate time for lung function measurements in infants, prior to environmental influences upon their respiratory tract. Tidal flow-volume loops, respiratory system compliance (Crs) and resistance (Rrs) (single breath passive occlusion technique) were measured in 24 healthy, awake awake infants, at one hour and on the following four days of life to investigat...

In normal subjects and patients with airway obstruction, flows during a forced vital capacity (FVC) manoeuvre are higher after a fast inspiration without an end-inspiratory pause (manoeuvre 1) as compared to a slow inspiration with an end-expiratory pause of approximately 5 s (manoeuvre 2). In this study, we investigated the influence of these manoeuvres on maximal expiratory volume-time and fl...

background: postoperative pulmonary dysfunction is one of the most frequent complications after cardiac surgery and it is believed to result from the use of cardiopulmonary bypass (cpb). in this study, we investigated the effect of low tidal volume ventilation during cpb on postoperative gas exchange and lung mechanics. methods: this prospective randomized study included 100 patients undergoing...

B ronchodilators remain the mainstay of chronic obstructive pulmonary disease (COPD) management and are recommended for the treatment of symptomatic patients at all stages of this disease [1]. For many years studies of these drugs focussed on changes in forced expiratory volume in one second (FEV1) or, occasionally, forced vital or slow vital capacity, believing that these robust and reproducib...

RATIONALE Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans. OBJECTIVES This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwell...

Background: To those patients with advanced lung cancer, the ultimate objective is to improve the quality of life, and lung function is an important factor affecting quality of life. We detect lung function of patients with lung cancer and study the correlation between lung function and the patients’ survival time, to provide reference for evaluation of disease progression and prognosis. Method...