Moderate to marked interstitial pneumonitis with many Pneumocystis organisms was found in rabbits treated with cortisone and antibiotics and instilled intranasally with a suspension of lung tissue from either a patient or a rabbit with this infection. Organisms and pulmonary lesions of similar severity and frequency were present in controls treated in the same manner but instilled with either s...

Streptococcus pneumoniae is an important cause of community-acquired pneumonia, meningitis, and bacteremia. The problem of pneumococcal disease is exacerbated by increasing drug resistance. Furthermore, patients with impaired immunity are at high risk for invasive pneumococcal infections. Thus, there is an urgent need for new approaches to antimicrobial therapy. Antibody therapies take advantag...

rese k exP^ore^ to the point at which further 0f ar<;h becomes useless, and advocate the use relt?n i0^ed animal experiments rather than the 1 y uncontrolled trials in the field. The ?J <aj_iuuiiuiuiicu LI1U.1S ll "11C ucm' Present paper deals with experiments carried out ^ 1936 and are recorded because the results that bacteriophage produced a definite elay in mortality. The experiment was car...

1. A single small dose of ethylhydrocuprein (optochin base), which by itself has practically no protective effect against experimental pneumococcal infection in mice, is capable of increasing the threshold value of the type homologous antipneumococcus serum at least fifty times. 2. This effect is proportionately many times greater than a simple summation of the protective effects of these two b...

REFERENCES A photograph of third-stage (L3) Anisakis simplex larvae in the gastric cavity of BALB/c mice is provided here. Anisakis nematodes (Figure A; arrows) are white and cylindrical and measure approximately 2 to 3 centimeters in length. Human anisakiasis, an emerging disease often triggered by eating fi sh infected with Anisakis sp., is not widely studied in Latin America. Mouse models ha...

The aim of the present study was to develop a reproducible porcine infection model with Brachyspira hyodysenteriae. The influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. Furthermore, the synergistic effect of additional bacteria (Escherichia coli O141, Bacteroides vulgatus or a mixtu...

Burkholderia pseudomallei is an intracellular Gram-negative bacterial pathogen intrinsically resistant to a variety of antibiotics. Phages have been developed for use as an alternative treatment therapy, particularly for bacterial infections that do not respond to conventional antibiotics. In this study, we investigated the use of phages to treat cells infected with B. pseudomallei. Phage C34 i...

Infectivity of Borrelia burgdorferi strain 297 in normal outbred ddY mice was examined. Strain 297 was inoculated intraperitoneally in 3-week-old outbred ddY mice. B. burgdorferi was routinely cultured from the heart and urinary bladder 5 to 84 days postinoculation. The combined isolation rate from both heart and urinary bladder was significantly higher than the rate from spleen, kidney, liver,...

1. The reaction of the chick embryo to nine strains of gonococci was studied. Four of these were inoculated intra-amniotically in 14 to 15 day embryos. 2. Infection of the 10 day chorio-allantoic membrane was localized and accompanied by polymorphonuclear leucocytic phagocytosis. 3. Infection was either transitory or persisted until hatching. Several strains killed the 10 day embryo in 3 days. ...