The field of theranostics is growing rapidly as therapeutic regimes are increasingly being integrated and guided by diagnostic practices such as medical imaging. There is some room for discussion about the general definition of a theranostic agent, if there exists such a definition. Is it a diagnostic imaging agent that is used in the context to guide surgical procedures? Or rather, is it a the...

A simple and fast HPLC method for the determination of porphyrins in bile without extraction is described. Porphyrins were determined in bile from control subjects and from patients after orthotopic liver transplantation, including three patients with erythropoietic protoporphyria. It was found that: 1) coproporphyrin I is the predominant porphyrin in bile of controls, accompanied by some copro...

The recent development by Craig (l-3) of an all-glass machine for liquidliquid counter-current fractionation makes possible the application of his method to the separation of porphyrins which cannot readily be separated by the sensitive Willstatter “HCl number” method. In this paper we have studied the application of the Craig method to the separation of a mixture of three known porphyrins, usi...

The role of hemin in the maintenance of protein synthesis in reticulocyte lysates was examined by comparing the effects of various porphyrins and metalloporphyrins on the protein kinase activity of the hemin-controlled repressor and on protein synthesis. The porphyrin requirements for maintenance of protein synthesis were relatively specific. Iron and cobalt metalloporphyrins sustained protein ...

In this manuscript, we report, the photophysical study of triplet excited states and antimicrobial photoinactivation positively charged tetra-cisplatin porphyrin derivatives against Gram + ? bacterial strains. Isomeric cisplatin-porphyrins were used applied in aPDT assays bacilli Escherichia coli, Klebsiella pneumoniae Pseudomonas aeruginosa (Gram negative) a cocci Staphylococcus aureus positiv...