This paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). Tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

• Mathematical model of drug release from drug-excipient granules. Developed can account for radial variations in porosity and content. Model accounts internal diffusion solubility-limited extraction granule. Solubility-limited give rise to a range moving boundary value problems. A reduced-order is presented the case which initial load greatly exceeds solubility Understanding pharmaceutical gra...

Background Colloidal silica is an inorganic substance widely used as excipient in pharmaceutical preparation. It acts as a vehicule to increase the absorption of many oral drug formulations. Many excipients have been reported to induce drug hypersensitivity such as tartrazine, aspartame, benzalkonium chloride, sodium metabisulphite, propyl gallate. However, colloidal silica has never been repor...

Lactose is available in several crystalline forms, which differ in binding properties. A new method of estimating the fragmentation propensity was applied to investigate the consolidation and compaction behaviour of this excipient for direct compression. Mercury porosimetry was used to demonstrate that crystalline lactose fragments during compaction. Tablet strength was found to be dependent on...