Plasma exchange has been proposed as a treatment for multiple disorders. Three patients with amyotropic lateral sclerosis, who were hemostatically normal, were studied through a total of 11 4-liter exchanges. Plasma was replaced by an equal volume of 5% albumin or 5% plasma protein fraction. Serial studies revealed that immediately after the exchange transfusion, there was significant prolongat...

BACKGROUND Severe neonatal hyperbilirubinemia is associated with significant morbidity and mortality. This study was conducted to investigate the causes of severe hyperbilirubinemia leading to Exchange Transfusion (ET) from March 2009 to March 2011 in Bahrami children hospital, Tehran, Iran in order to establish guidelines to prevent profound jaundice & ET. METHODS 94 neonates underwent ET fo...

I HE CONTROL of red cell productiomi is undoubtedly geared toward maintaining the red cell mass at a functionally optimal size. Since the primary function of the red cell mass is to transport oxygen to the tissues, it is generally assumed that the control is triggered by the tissue tension of oxygen. Recent studies indicate that the oxygen tension in one target area, the kidney, is inversely pr...

The occurrence of thrombocytopenic purpura in babies born to mothers with idiopathic thrombocytopenia is a well recognized though uncommon clinical entity. Robson and Walker (1951) were able to collect from the literature only 19 definite and nine probable examples of this association. The suggestion of Epstein, Lozner, Cobbey and Davidson (1950) that this type of congenital thrombocytopenic pu...

Cases of Rhesus incompatibility resulting in the condition known as hydrops foetalis do badly. Mollison and Cutbush (1954) state 'it is doubtful if infants born with ascites ever survive', and it is difficult to find any record of survival. Heilig, Tudor, Smith and Platou (1948) report two cases of hydrops, one of which survived with a hemiplegia. Van Loghem, van Bolhuis, Soeters and Veeneklaas...

In experienced hands exchange transfusion carries a very low operative risk. Nevertheless, infants who are initially very anaemic present a grave problem as this treatment is their only hope of survival. There are also other infants who appear well at the start of the transfusion, but become ill or die during the procedure. Walker and Neligan (1955) discussed these problems and listed the proba...

The objective of this study was to examine the use of partial exchange transfusion (PET) performed for polycythemia hyperviscosity syndrome (PHS) over time. A retrospective review of 141 infants who received a PET for PHS at Yale-New Haven Hospital between 1986 and 2007 was performed, querying maternal and neonatal medical records. Patient demographics, risk factors for PHS, indications for PET...

Blood pressure changes as a function of the rates of blood withdrawal and infusion were determined during exchange blood transfusion in 2 preterm newborn infants. 10 ml blood withdrawal and infusion completed within 3 minutes resulted in reversible changes in aortic pressure, whereas the same procedure completed within 45 to 60 seconds resulted in a progressive fall in the systolic pressure and...

The development of exchange transfusion has greatly altered the prognosis of haemolytic disease of the newborn and the procedure is now accepted as being essential in cases of any severity. It is carried out wherever the criteria for operation are fulfilled and by operators of varying skill and experience. The difficulties associated with blood transfusion have received increasing attention in ...

During a five and a half year period, exchange transfusions were performed through the peripheral vessels in 201 of the 214 infants (94%) who required either double volume or partial plasma exchange transfusions. Peripheral vessel exchange transfusion is simple, practicable, and safe with few complications. Technical difficulties in catheterizing the peripheral artery and vein may be overcome b...